N-[1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-4-phenoxy-benzenesulfonamide

Base Information

• Chemical Name: N-[1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-4-phenoxy-benzenesulfonamide
• CAS No.: 186551-87-1
• Molecular Formula: C₂₄H₂₁N₃O₄S
• Molecular Weight: 447.514

Synonyms:N-[1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-4-phenoxy-benzenesulfonamide

Chemical Property of N-[1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-4-phenoxy-benzenesulfonamide

Chemical Property:

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Technology Process of N-[1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-4-phenoxy-benzenesulfonamide

There total 2 articles about N-[1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-4-phenoxy-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(3-cyanobenzyl)-2-oxopyrrolidin-3(S)-yl]carbamic acid tert-butyl ester (186550-17-4) → N-[1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-4-phenoxy-benzenesulfonamide (186551-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 7.3 g / HCl / ethyl acetate / 4 h / 20 °C

2: Et₃N / CH₂Cl₂ / 2 h

With hydrogenchloride; triethylamine; In dichloromethane; ethyl acetate; 1: acidolysis / 2: Condensation;

DOI:10.1021/jm990040h

Reference yield:

4-phenoxyphenylsulfonyl chloride (1623-92-3) + 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride → N-[1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-4-phenoxy-benzenesulfonamide (186551-87-1)

Guidance literature:

With triethylamine; In dichloromethane; for 2h;

DOI:10.1021/jm990040h

Reference yield:

N-[1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-4-phenoxy-benzenesulfonamide (186551-87-1) → 3-[(S)-2-Oxo-3-(4-phenoxy-benzenesulfonylamino)-pyrrolidin-1-ylmethyl]-benzimidoyl chloride

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 6h;

DOI:10.1021/jm990040h

upstream raw materials:

4-phenoxyphenylsulfonyl chloride

[1-(3-cyanobenzyl)-2-oxopyrrolidin-3(S)-yl]carbamic acid tert-butyl ester

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