3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((1-(methylsulfonyl)-4-phenylpiperidin-4-yl)methyl)picolinamide hydrochloride

Base Information

• Chemical Name: 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((1-(methylsulfonyl)-4-phenylpiperidin-4-yl)methyl)picolinamide hydrochloride
• CAS No.: 1071484-06-4
• Molecular Formula: C₂₈H₂₉FN₆O₃S₃*ClH
• Molecular Weight: 649.234
• Mol file: 1071484-06-4.mol

Synonyms:3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((1-(methylsulfonyl)-4-phenylpiperidin-4-yl)methyl)picolinamide hydrochloride

Chemical Property of 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((1-(methylsulfonyl)-4-phenylpiperidin-4-yl)methyl)picolinamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((1-(methylsulfonyl)-4-phenylpiperidin-4-yl)methyl)picolinamide hydrochloride

There total 6 articles about 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((1-(methylsulfonyl)-4-phenylpiperidin-4-yl)methyl)picolinamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((1-(methylsulfonyl)-4-phenylpiperidin-4-yl)methyl)picolinamide (1071485-75-0) → 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((1-(methylsulfonyl)-4-phenylpiperidin-4-yl)methyl)picolinamide hydrochloride (1071484-06-4)

Guidance literature:

With hydrogenchloride; In methanol;

Reference yield:

4-phenyl-4-cyanopiperidine (40481-13-8) → 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((1-(methylsulfonyl)-4-phenylpiperidin-4-yl)methyl)picolinamide hydrochloride (1071484-06-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 2 h / 23 °C

2.1: hydrogen; acetic acid / platinum(IV) oxide / methanol / 264 h / 2585.81 Torr

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 48 h / 23 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 23 °C

4.2: pH ~ 7

5.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 23 °C

6.1: hydrogenchloride / methanol

With hydrogenchloride; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; platinum(IV) oxide; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;

Reference yield:

tert-butyl 4-cyano-4-phenylpiperidine-1-carboxylate (158144-79-7) → 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((1-(methylsulfonyl)-4-phenylpiperidin-4-yl)methyl)picolinamide hydrochloride (1071484-06-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogen; acetic acid / platinum(IV) oxide / methanol / 264 h / 2585.81 Torr

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 48 h / 23 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 23 °C

3.2: pH ~ 7

4.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 23 °C

5.1: hydrogenchloride / methanol

With hydrogenchloride; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; platinum(IV) oxide; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;

upstream raw materials:

3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((1-(methylsulfonyl)-4-phenylpiperidin-4-yl)methyl)picolinamide

4-phenyl-4-cyanopiperidine

3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((4-phenylpiperidin-4-yl)methyl)picolinamide

tert-butyl 4-((3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamido)methyl)-4-phenylpiperidine-1-carboxylate