(1-benzyl-6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

Base Information

Chemical Name:(1-benzyl-6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone
CAS No.:1333162-79-0
Molecular Formula:C₂₆H₂₇NO₃
Molecular Weight:401.505
Hs Code.:

Synonyms:(1-benzyl-6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

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Chemical Property of (1-benzyl-6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

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Technology Process of (1-benzyl-6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

There total 3 articles about (1-benzyl-6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1333162-70-1
N-(2-(2-hydroxy-1-phenylpropan-2-yl)-4,5-dimethoxyphenethyl)benzamide

: 1333162-86-9
C₂₆H₂₇NO₃

: 1333162-79-0
(1-benzyl-6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.3390/molecules16087019

Reference yield:

: 67616-16-4
N-[2-(3,4-dimethoxyphenyl)ethyl]benzamide

: 1333162-86-9
C₂₆H₂₇NO₃

: 1333162-79-0
(1-benzyl-6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: polyphosphoric acid / dichloromethane / 20 h / 60 °C

2.1: magnesium / diethyl ether / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / dichloromethane / 0.5 h / 20 °C

With toluene-4-sulfonic acid; magnesium; In diethyl ether; dichloromethane; 1.1: Friedel Crafts acylation;
DOI:10.3390/molecules16087019

Reference yield:

: 183020-75-9
N-(4,5-dimethoxy-2-(2-phenylacetyl)phenethyl)benzamide

: 1333162-86-9
C₂₆H₂₇NO₃

: 1333162-79-0
(1-benzyl-6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium / diethyl ether / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / dichloromethane / 0.5 h / 20 °C

With toluene-4-sulfonic acid; magnesium; In diethyl ether; dichloromethane;
DOI:10.3390/molecules16087019