N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)-phenyl)-C,C,C-trifluoro-methanesulfonamide

Base Information

Chemical Name:N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)-phenyl)-C,C,C-trifluoro-methanesulfonamide
CAS No.:1617505-83-5
Molecular Formula:C₂₀H₁₆F₃NO₄S₂
Molecular Weight:455.479
Hs Code.:

Synonyms:N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)-phenyl)-C,C,C-trifluoro-methanesulfonamide

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Chemical Property of N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)-phenyl)-C,C,C-trifluoro-methanesulfonamide

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Technology Process of N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)-phenyl)-C,C,C-trifluoro-methanesulfonamide

There total 4 articles about N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)-phenyl)-C,C,C-trifluoro-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 421-83-0
trifluoromethane sulfonyl chloride

: 1617505-82-4
(3-amino-phenyl)(5-(3-ethoxy-phenyl)-thiophen-2-yl)methanone

: 1617505-83-5
N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)-phenyl)-C,C,C-trifluoro-methanesulfonamide

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1016/j.ejmech.2014.05.074

Reference yield:

: 121-90-4
m-nitrobenzoic acid chloride

: 1617505-83-5
N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)-phenyl)-C,C,C-trifluoro-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride / dichloromethane / 0 - 20 °C

2: tin(II) chloride dihdyrate / methanol / 2 h / Reflux

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / Inert atmosphere; Reflux

4: pyridine / 20 °C

With pyridine; aluminum (III) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; caesium carbonate; In methanol; 1,2-dimethoxyethane; dichloromethane; water; 1: |Friedel-Crafts Acylation / 3: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.05.074

Reference yield:

: 269745-89-3
(5-bromo-thiophen-2-yl)-(3-nitrophenyl)methanone

: 1617505-83-5
N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)-phenyl)-C,C,C-trifluoro-methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tin(II) chloride dihdyrate / methanol / 2 h / Reflux

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / Inert atmosphere; Reflux

3: pyridine / 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; caesium carbonate; In methanol; 1,2-dimethoxyethane; water; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.05.074