methyl 5-(4-methoxycarbonyl-thiazol-2-yl)-3-trifluoromethanesulfonyloxy-6-(1-triisopropylsilyloxy-vinyl)-pyridine-2-carboxylate

Base Information

Chemical Name:methyl 5-(4-methoxycarbonyl-thiazol-2-yl)-3-trifluoromethanesulfonyloxy-6-(1-triisopropylsilyloxy-vinyl)-pyridine-2-carboxylate
CAS No.:942057-02-5
Molecular Formula:C₂₄H₃₁F₃N₂O₈S₂Si
Molecular Weight:624.731
Hs Code.:

Synonyms:methyl 5-(4-methoxycarbonyl-thiazol-2-yl)-3-trifluoromethanesulfonyloxy-6-(1-triisopropylsilyloxy-vinyl)-pyridine-2-carboxylate

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Chemical Property of methyl 5-(4-methoxycarbonyl-thiazol-2-yl)-3-trifluoromethanesulfonyloxy-6-(1-triisopropylsilyloxy-vinyl)-pyridine-2-carboxylate

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Technology Process of methyl 5-(4-methoxycarbonyl-thiazol-2-yl)-3-trifluoromethanesulfonyloxy-6-(1-triisopropylsilyloxy-vinyl)-pyridine-2-carboxylate

There total 1 articles about methyl 5-(4-methoxycarbonyl-thiazol-2-yl)-3-trifluoromethanesulfonyloxy-6-(1-triisopropylsilyloxy-vinyl)-pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 942057-03-6
C₁₅H₁₁SO₈F₃N₂S

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 942057-02-5
methyl 5-(4-methoxycarbonyl-thiazol-2-yl)-3-trifluoromethanesulfonyloxy-6-(1-triisopropylsilyloxy-vinyl)-pyridine-2-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 13h;
DOI:10.1021/jo0703505

Reference yield:

: 942057-02-5
methyl 5-(4-methoxycarbonyl-thiazol-2-yl)-3-trifluoromethanesulfonyloxy-6-(1-triisopropylsilyloxy-vinyl)-pyridine-2-carboxylate

: methyl 6-[2-(1'-allyloxycarbonylamino-2'-tritylsulfanyl-ethyl)-thiazol-4-yl]-5-(4-methoxycarbonyl-thiazol-2-yl)-3-trifluoromethanesulfonyloxy-pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / N-bromosuccinimide / tetrahydrofuran; aq. phosphate buffer / 0.5 h / 20 °C / pH 7

2.1: KHCO₃ / tetrahydrofuran / 50 h / -40 - 20 °C

2.2: 69 percent / trifluoroacetic anhydride; 2,6-lutidine / tetrahydrofuran / 2 h / -20 °C

With N-Bromosuccinimide; potassium hydrogencarbonate; In tetrahydrofuran; phosphate buffer;
DOI:10.1021/jo0703505

Reference yield:

: 942057-02-5
methyl 5-(4-methoxycarbonyl-thiazol-2-yl)-3-trifluoromethanesulfonyloxy-6-(1-triisopropylsilyloxy-vinyl)-pyridine-2-carboxylate

: methyl 6-[2-(1'-allyloxycarbonylamino-2'-tritylsulfanyl-ethyl)-thiazol-4-yl]-5-(4-methoxycarbonyl-thiazol-2-yl)-3-trifluoromethanesulfonyloxy-pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / N-bromosuccinimide / tetrahydrofuran; aq. phosphate buffer / 0.5 h / 20 °C / pH 7

2.1: KHCO₃ / tetrahydrofuran / 50 h / -40 - 20 °C

2.2: trifluoroacetic anhydride; 2,6-lutidine / tetrahydrofuran / 2 h / -20 °C

With N-Bromosuccinimide; potassium hydrogencarbonate; In tetrahydrofuran; phosphate buffer;
DOI:10.1021/jo0703505