4-[(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamino]-2-oxo-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-1-yl]-benzonitrile tosylate

Base Information

Chemical Name:4-[(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamino]-2-oxo-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-1-yl]-benzonitrile tosylate
CAS No.:1192355-69-3
Molecular Formula:C₇H₈O₃S*C₂₇H₂₂F₆N₄O₂
Molecular Weight:720.692
Hs Code.:

Synonyms:4-[(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamino]-2-oxo-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-1-yl]-benzonitrile tosylate

Suppliers and Price of 4-[(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamino]-2-oxo-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-1-yl]-benzonitrile tosylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamino]-2-oxo-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-1-yl]-benzonitrile tosylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamino]-2-oxo-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-1-yl]-benzonitrile tosylate

There total 12 articles about 4-[(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamino]-2-oxo-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-1-yl]-benzonitrile tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1192355-48-8
4-[(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamino]-2-oxo-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-1-yl]-benzonitrile

: 104-15-4
toluene-4-sulfonic acid

: 1192355-69-3
4-[(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamino]-2-oxo-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-1-yl]-benzonitrile tosylate

Guidance literature:: In dichloromethane;

Reference yield:

: 39890-95-4
2-chloro-6-trifluoromethylpyridine

: 1192355-69-3
4-[(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamino]-2-oxo-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-1-yl]-benzonitrile tosylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / 17 h / 60 °C

2.1: tetrahydrofuran; tert-butyl methyl ether / 8 - 16 °C

2.2: 0 °C

3.1: sulfuric acid / 0 - 45 °C

4.1: hydrogenchloride / water / 16 h / 90 °C

4.2: 15 °C / pH 13

5.1: water / 18 h / Reflux

6.1: sodium cyanoborohydride; acetic acid / 1 h / 20 °C

7.1: dichloromethane

With hydrogenchloride; sulfuric acid; sodium cyanoborohydride; acetic acid; triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; water;

Reference yield:

: 1192356-23-2
2-(6-trifluoromethyl-pyridin-2-yl)-propan-2-ol

: 1192355-69-3
4-[(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamino]-2-oxo-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-1-yl]-benzonitrile tosylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 0 - 45 °C

2.1: hydrogenchloride / water / 16 h / 90 °C

2.2: 15 °C / pH 13

3.1: water / 18 h / Reflux

4.1: sodium cyanoborohydride; acetic acid / 1 h / 20 °C

5.1: dichloromethane

With hydrogenchloride; sulfuric acid; sodium cyanoborohydride; acetic acid; In dichloromethane; water;