(R)-2-(1-Aminoethyl)phenol

Base Information

• Chemical Name: (R)-2-(1-Aminoethyl)phenol
• CAS No.: 123983-05-1
• Molecular Formula: C8H11 N O
• Molecular Weight: 137.181
• Hs Code.: 2922299090
• European Community (EC) Number: 802-712-4
• DSSTox Substance ID: DTXSID20455290
• Nikkaji Number: J1.035.157J
• Wikidata: Q76416634
• Mol file: 123983-05-1.mol

Synonyms:(R)-2-(1-Aminoethyl)phenol;123983-05-1;2-[(1R)-1-aMinoethyl]phenol;Phenol, 2-[(1R)-1-aminoethyl]-;2-[(1R)-1-aminoethyl]-phenol;2-(1-amino-ethyl)-phenol;2-[(R)-1-Aminoethyl]phenol;SCHEMBL7675674;2-[(1r)-1-aminoethyl] phenol;DTXSID20455290;YEA98305;MFCD06761853;AKOS012672146;AS-35722;2-[(1R)-1-Aminoethyl]-phenol, AldrichCPR;CS-0000266;EN300-365680;A848317;A890623

Chemical Property of (R)-2-(1-Aminoethyl)phenol

Chemical Property:

• Vapor Pressure: 0.017mmHg at 25°C
• Melting Point: 83 °C
• Boiling Point: 246.289°C at 760 mmHg
• PKA: 9.99±0.35(Predicted)
• Flash Point: 102.752°C
• PSA: 46.25000
• Density: 1.097g/cm³
• LogP: 2.11220
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-(1-Aminoethyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1O)N
• Isomeric SMILES: C[C@H](C1=CC=CC=C1O)N

Technology Process of (R)-2-(1-Aminoethyl)phenol

There total 13 articles about (R)-2-(1-Aminoethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-<(1R)-1-(<(1'R)-1'-phenylethyl>amino)ethyl>phenol (223268-30-2) → 2?[(1R)?1-aminoethyl]phenol (123983-05-1)

Guidance literature:

With hydrogen; acetic acid; palladium dihydroxide; In methanol; at 20 ℃; for 48h; under 3040 Torr;

DOI:10.1002/hlca.200490054

Reference yield: 88.0%

(1R)-1-[2-(methoxymethoxy)phenyl]ethanamine (368447-78-3) → 2?[(1R)?1-aminoethyl]phenol (123983-05-1)

Guidance literature:

With hydrogenchloride; In methanol; water; Heating;

DOI:10.1016/S0040-4039(01)00910-8

Reference yield: 70.0%

(R)-1-(2-methoxyphenyl)ethylamine (40023-74-3,62409-14-7,68285-23-4,68285-24-5) → 2?[(1R)?1-aminoethyl]phenol (123983-05-1)

Guidance literature:

With aluminum tri-bromide; In benzene; at 20 ℃; for 20h;

DOI:10.1002/hlca.200490054

upstream raw materials:

(1R)-1-[2-(methoxymethoxy)phenyl]ethanamine

(R)-1-(2-methoxyphenyl)ethylamine

2-<(1R)-1-(<(1'R)-1'-phenylethyl>amino)ethyl>phenol

2-methoxymethoxybenzaldehyde (E)-O-[(1S)-2-hydroxy-1-phenylethyl]oxime

Downstream raw materials:

1-[(R)-1-(2-Hydroxy-phenyl)-ethyl]-piperidine-2,6-dione

{(R)-1-[(R)-1-(2-Methoxy-phenyl)-ethyl]-6-oxo-piperidin-2-yl}-acetaldehyde

(R)-6-Allyl-1-[(R)-1-(2-hydroxy-phenyl)-ethyl]-piperidin-2-one

C₂₁H₂₀N₄O₂