Technology Process of 2,6-di-tert-butyl-4,8-diphenyl-1,5-diazocine
There total 2 articles about 2,6-di-tert-butyl-4,8-diphenyl-1,5-diazocine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C26H32N2;
With
n-butyllithium;
In
tetrahydrofuran; diethyl ether; hexane;
at -78 - 20 ℃;
for 2.16667h;
Inert atmosphere;
With
tert-butylhypochlorite;
In
tetrahydrofuran; diethyl ether; hexane;
at 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/ja305581f
- Guidance literature:
-
2,3-diphenyl-1,4-diiodo-1,3-diene;
With
tert.-butyl lithium;
In
diethyl ether; pentane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
Schlenk technique;
tert-butyl isocyanide;
In
diethyl ether; pentane;
at -78 ℃;
Inert atmosphere;
Schlenk technique;
Reflux;
With
tert-butylhypochlorite;
In
diethyl ether; pentane;
at 25 ℃;
for 2h;
Inert atmosphere;
Schlenk technique;
DOI:10.1021/acs.orglett.7b03917
- Guidance literature:
-
With
titanium tetrachloride;
In
toluene;
at -78 - 60 ℃;
for 5h;
Reagent/catalyst;
Inert atmosphere;
Schlenk technique;
DOI:10.1021/acs.orglett.7b03917
