(R)-o-Methyl-a-phenethylamine

Base Information

• Chemical Name: (R)-o-Methyl-a-phenethylamine
• CAS No.: 105615-45-0
• Molecular Formula: C9H13 N
• Molecular Weight: 135.209
• Hs Code.: 2921499090
• Mol file: 105615-45-0.mol

Synonyms:Benzenemethanamine,a,2-dimethyl-, (R)-; (R)-o-Methyl-a-phenethylamine; (R)-o-Methyl-a-phenylethylamine

Chemical Property of (R)-o-Methyl-a-phenethylamine

Chemical Property:

• Melting Point: 158 °C
• Boiling Point: 209.3±9.0 °C(Predicted)
• PKA: 9.22±0.10(Predicted)
• PSA: 26.02000
• Density: 0.945±0.06 g/cm3(Predicted)
• LogP: 2.71500

Purity/Quality:

98%min ^*data from raw suppliers

{2-[DiMethyl- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-o-Methyl-a-phenethylamine

There total 19 articles about (R)-o-Methyl-a-phenethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(R)-2-methyl-N-((R)-1-(o-tolyl)ethyl)propane-2-sulfinamide → [(1R)-1-(2-methylphenyl)ethyl]amine (105615-45-0)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.15227/orgsyn.090.0338

Reference yield: 96.15%

(R)-2-methyl-N-(1-(o-tolyl)ethyl)propane-2-sulfonamide → [(1R)-1-(2-methylphenyl)ethyl]amine (105615-45-0)

Guidance literature:

With aluminum (III) chloride; methoxybenzene; In dichloromethane; at 30 ℃; for 2h;

Reference yield: 96.0%

(R)-N-[1-(2-methylphenyl)ethylidene]-2-methylpropane-2-sulfinamide → [(1R)-1-(2-methylphenyl)ethyl]amine (105615-45-0)

Guidance literature:

(R)-N-[1-(2-methylphenyl)ethylidene]-2-methylpropane-2-sulfinamide; With [RhCl₂(p-cymene)]2; potassium tert-butylate; 2-Amino-2-methyl-1-propanol; isopropyl alcohol; at 50 ℃; for 0.5h; Inert atmosphere; Microwave irradiation; Molecular sieve;

With hydrogenchloride; In methanol; at 20 ℃; enantioselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201402884

upstream raw materials:

(1R,1'R)-N-(1'-phenylethyl)-1-(2''-methylphenyl)ethylamine

1-(o-tolyl)ethanamine

2-Methylacetophenone

(S)-1-phenyl-N-((S)-1-(2-(methyl)phenyl)ethyl)ethanamine

Downstream raw materials:

(R)-N-(1-o-tolylethyl)benzamide

Refernces

• 1、 Yoon, Sanghan,Patil, Mahesh D.,Sarak, Sharad,Jeon, Hyunwoo,Kim, Geon-Hee,Khobragade, Taresh P.,Sung, Sihyong,Yun, Hyungdon. "Deracemization of Racemic Amines to Enantiopure (R)- and (S)-amines by Biocatalytic Cascade Employing ω-Transaminase and Amine Dehydrogenase". . p. 1898 - 1902. Retrieved 2019.
• 2、 Tan, Xuefeng,Gao, Shuang,Zeng, Weijun,Xin, Shan,Yin, Qin,Zhang, Xumu. "Asymmetric Synthesis of Chiral Primary Amines by Ruthenium-Catalyzed Direct Reductive Amination of Alkyl Aryl Ketones with Ammonium Salts and Molecular H2". supporting information. p. 2024 - 2027. Retrieved 2018/02/19.