1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythropentofuranosyl]-4-{[(N,N-dimethylamino)methylidene]amino}-3-(octa-1,7-diyn-1-yl)-1H-pyrazolo[3,4-d]pyrimidine

Base Information

Chemical Name:1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythropentofuranosyl]-4-{[(N,N-dimethylamino)methylidene]amino}-3-(octa-1,7-diyn-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS No.:1240371-95-2
Molecular Formula:C₄₂H₄₄N₆O₅
Molecular Weight:712.849
Hs Code.:

1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythropentofuranosyl]-4-{[(N,N-dimethylamino)methylidene]amino}-3-(octa-1,7-diyn-1-yl)-1H-pyrazolo[3,4-d]pyrimidine

Synonyms:1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythropentofuranosyl]-4-{[(N,N-dimethylamino)methylidene]amino}-3-(octa-1,7-diyn-1-yl)-1H-pyrazolo[3,4-d]pyrimidine

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Chemical Property of 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythropentofuranosyl]-4-{[(N,N-dimethylamino)methylidene]amino}-3-(octa-1,7-diyn-1-yl)-1H-pyrazolo[3,4-d]pyrimidine

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Technology Process of 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythropentofuranosyl]-4-{[(N,N-dimethylamino)methylidene]amino}-3-(octa-1,7-diyn-1-yl)-1H-pyrazolo[3,4-d]pyrimidine

There total 8 articles about 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythropentofuranosyl]-4-{[(N,N-dimethylamino)methylidene]amino}-3-(octa-1,7-diyn-1-yl)-1H-pyrazolo[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1240371-94-1
1-[2-deoxy-β-D-erythropentofuranosyl]-3-(octa-1,7-diyn-1-yl)-4-{[(N,N-dimethylamino)methylidene]amino}-1H-pyrazolo[3,4-d]pyrimidine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1240371-95-2
1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythropentofuranosyl]-4-{[(N,N-dimethylamino)methylidene]amino}-3-(octa-1,7-diyn-1-yl)-1H-pyrazolo[3,4-d]pyrimidine

Guidance literature:: With pyridine; at 20 ℃; for 6h;
DOI:10.1021/bc100090y

Reference yield:

: 871-84-1
1,7-Octadiyne

: 1240371-95-2
1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythropentofuranosyl]-4-{[(N,N-dimethylamino)methylidene]amino}-3-(octa-1,7-diyn-1-yl)-1H-pyrazolo[3,4-d]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2: methanol; sodium methylate / 8 h / 20 °C

3: methanol; ammonia / 6 h / 100 °C / Autoclave

4: methanol / 0.5 h / 20 °C

5: pyridine / 6 h / 20 °C

With pyridine; methanol; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; sodium methylate; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/bc100090y

Reference yield:

: 1-[2-deoxy-β-D-erythropentofuranosyl]-3-(octa-1,7-diyn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 1240371-95-2
1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythropentofuranosyl]-4-{[(N,N-dimethylamino)methylidene]amino}-3-(octa-1,7-diyn-1-yl)-1H-pyrazolo[3,4-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 0.5 h / 20 °C

2: pyridine / 6 h / 20 °C

With pyridine; In methanol;
DOI:10.1021/bc100090y