(S)-methyl 2-(7-(4-((allyloxy)methyl)-4-methylpiperidin-1-yl)-2-(2‘-(but-3-en-1-yl)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

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Chemical Name:(S)-methyl 2-(7-(4-((allyloxy)methyl)-4-methylpiperidin-1-yl)-2-(2‘-(but-3-en-1-yl)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate
CAS No.:1567221-23-1
Molecular Formula:C₄₀H₅₀N₄O₄
Molecular Weight:650.861
Hs Code.:

(S)-methyl 2-(7-(4-((allyloxy)methyl)-4-methylpiperidin-1-yl)-2-(2‘-(but-3-en-1-yl)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Synonyms:(S)-methyl 2-(7-(4-((allyloxy)methyl)-4-methylpiperidin-1-yl)-2-(2‘-(but-3-en-1-yl)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

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Chemical Property of (S)-methyl 2-(7-(4-((allyloxy)methyl)-4-methylpiperidin-1-yl)-2-(2‘-(but-3-en-1-yl)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

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Technology Process of (S)-methyl 2-(7-(4-((allyloxy)methyl)-4-methylpiperidin-1-yl)-2-(2‘-(but-3-en-1-yl)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

There total 2 articles about (S)-methyl 2-(7-(4-((allyloxy)methyl)-4-methylpiperidin-1-yl)-2-(2‘-(but-3-en-1-yl)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1334402-81-1
(2-(but-3-en-1-yl)phenyl)boronic acid

: 1567221-17-3
(S)-methyl 2-(7-(4-((allyloxy)methyl)-4-methylpiperidin-1-yl)-2-(3-bromophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

: 1567221-23-1
(S)-methyl 2-(7-(4-((allyloxy)methyl)-4-methylpiperidin-1-yl)-2-(2‘-(but-3-en-1-yl)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; N,N-dimethyl-formamide; at 90 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 71813-50-8
1-bromo-2-(but-3-enyl)benzene

: 1567221-23-1
(S)-methyl 2-(7-(4-((allyloxy)methyl)-4-methylpiperidin-1-yl)-2-(2‘-(but-3-en-1-yl)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.08 h / -90 °C / Inert atmosphere

1.2: 0.75 h / 0 °C / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide; water / 1 h / 90 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; pentane;