4-[[4-[(diethylamino)carbonyl]phenyl](3-nitrophenyl)methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:4-[[4-[(diethylamino)carbonyl]phenyl](3-nitrophenyl)methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
CAS No.:728917-27-9
Molecular Formula:C₂₈H₃₅N₃O₅
Molecular Weight:493.603
Hs Code.:

Synonyms:4-[[4-[(diethylamino)carbonyl]phenyl](3-nitrophenyl)methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Suppliers and Price of 4-[[4-[(diethylamino)carbonyl]phenyl](3-nitrophenyl)methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[[4-[(diethylamino)carbonyl]phenyl](3-nitrophenyl)methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[[4-[(diethylamino)carbonyl]phenyl](3-nitrophenyl)methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

There total 7 articles about 4-[[4-[(diethylamino)carbonyl]phenyl](3-nitrophenyl)methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13331-27-6
m-nitrobenzene boronic acid

: 209808-18-4
4-[Bromo-(4-diethylcarbamoyl-phenyl)-methylene]-piperidine-1-carboxylic acid tert-butyl ester

: 728917-27-9
4-[[4-[(diethylamino)carbonyl]phenyl](3-nitrophenyl)methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In toluene; at 85 ℃; for 5h;
DOI:10.1021/jm000229p

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 728917-27-9
4-[[4-[(diethylamino)carbonyl]phenyl](3-nitrophenyl)methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: LDA / tetrahydrofuran / -78 - 20 °C

1.2: tetrahydrofuran; hexane / 12 h / 20 °C

2.1: 78 percent / Br₂; K₂CO₃ / CH₂Cl₂ / 1.5 h / 20 °C

3.1: 87 percent / 2 M NaOH; MeOH / 3 h / 40 °C

4.1: CH₂Cl₂ / 0.33 h / -20 °C

5.1: CH₂Cl₂ / 1.5 h / 20 °C

6.1: 2 M Na₂CO₃; tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene / 5 h / 85 °C

With methanol; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium carbonate; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; toluene; 1.2: Wittig-Horner olefination / 6.1: Suzuki coupling;
DOI:10.1021/jm000229p

Reference yield:

: 209808-15-1
4-(4-methoxycarbonylbenzylidene)piperidine-1-carboxylic acid tert-butyl ester

: 728917-27-9
4-[[4-[(diethylamino)carbonyl]phenyl](3-nitrophenyl)methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / Br₂; K₂CO₃ / CH₂Cl₂ / 1.5 h / 20 °C

2: 87 percent / 2 M NaOH; MeOH / 3 h / 40 °C

3: CH₂Cl₂ / 0.33 h / -20 °C

4: CH₂Cl₂ / 1.5 h / 20 °C

5: 2 M Na₂CO₃; tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene / 5 h / 85 °C

With methanol; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium carbonate; potassium carbonate; In dichloromethane; toluene; 5: Suzuki coupling;
DOI:10.1021/jm000229p