1-[(4R,5S,6R)-2-(4-Methoxy-phenyl)-5-methyl-6-((E)-propenyl)-[1,3]dioxan-4-yl]-butan-2-one

Base Information

Chemical Name:1-[(4R,5S,6R)-2-(4-Methoxy-phenyl)-5-methyl-6-((E)-propenyl)-[1,3]dioxan-4-yl]-butan-2-one
CAS No.:213403-39-5
Molecular Formula:C₁₉H₂₆O₄
Molecular Weight:318.413
Hs Code.:

Synonyms:1-[(4R,5S,6R)-2-(4-Methoxy-phenyl)-5-methyl-6-((E)-propenyl)-[1,3]dioxan-4-yl]-butan-2-one

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Chemical Property of 1-[(4R,5S,6R)-2-(4-Methoxy-phenyl)-5-methyl-6-((E)-propenyl)-[1,3]dioxan-4-yl]-butan-2-one

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Technology Process of 1-[(4R,5S,6R)-2-(4-Methoxy-phenyl)-5-methyl-6-((E)-propenyl)-[1,3]dioxan-4-yl]-butan-2-one

There total 6 articles about 1-[(4R,5S,6R)-2-(4-Methoxy-phenyl)-5-methyl-6-((E)-propenyl)-[1,3]dioxan-4-yl]-butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 213403-34-0
(E)-(5R,6S,7R)-5-Hydroxy-7-(4-methoxy-benzyloxy)-6-methyl-dec-8-en-3-one

: 213403-39-5
1-[(4R,5S,6R)-2-(4-Methoxy-phenyl)-5-methyl-6-((E)-propenyl)-[1,3]dioxan-4-yl]-butan-2-one

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 0 ℃; for 1.5h;
DOI:10.1021/jo001377q

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 213403-39-5
1-[(4R,5S,6R)-2-(4-Methoxy-phenyl)-5-methyl-6-((E)-propenyl)-[1,3]dioxan-4-yl]-butan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / 10-camphorsulfonic acid / CH₂Cl₂; hexane / 14 h / 25 °C

2: 50 percent / AD-mix-α / 2-methyl-propan-2-ol; H2O / 19 h / 25 °C

3: 95 percent / NaIO₄ / methanol; H₂O / 0.5 h / 25 °C

4: 60 percent / BF₃*Et₂O / CH₂Cl₂ / 1 h / -78 °C

5: 69 percent / DDQ / CH₂Cl₂ / 1.5 h / 0 °C

With sodium periodate; AD-mix-α; boron trifluoride diethyl etherate; (1S)-10-camphorsulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; hexane; dichloromethane; water; tert-butyl alcohol; 2: Sharpless dihydroxylation / 4: Mukaiyama aldol reaction;
DOI:10.1021/jo001377q

Reference yield:

: 213403-25-9
(E)-(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methyl-hex-4-enal

: 213403-39-5
1-[(4R,5S,6R)-2-(4-Methoxy-phenyl)-5-methyl-6-((E)-propenyl)-[1,3]dioxan-4-yl]-butan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / BF₃*Et₂O / CH₂Cl₂ / 1 h / -78 °C

2: 69 percent / DDQ / CH₂Cl₂ / 1.5 h / 0 °C

With boron trifluoride diethyl etherate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; 1: Mukaiyama aldol reaction;
DOI:10.1021/jo001377q