(2R,3S)-methyl 2-fluoro-2-((R)-hydroxy(4-methoxyphenyl)methyl)-3-phenylpentanoate

Base Information

Chemical Name:(2R,3S)-methyl 2-fluoro-2-((R)-hydroxy(4-methoxyphenyl)methyl)-3-phenylpentanoate
CAS No.:1345023-40-6
Molecular Formula:C₂₀H₂₃FO₄
Molecular Weight:346.399
Hs Code.:

Synonyms:(2R,3S)-methyl 2-fluoro-2-((R)-hydroxy(4-methoxyphenyl)methyl)-3-phenylpentanoate

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Chemical Property of (2R,3S)-methyl 2-fluoro-2-((R)-hydroxy(4-methoxyphenyl)methyl)-3-phenylpentanoate

Chemical Property:

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Technology Process of (2R,3S)-methyl 2-fluoro-2-((R)-hydroxy(4-methoxyphenyl)methyl)-3-phenylpentanoate

There total 4 articles about (2R,3S)-methyl 2-fluoro-2-((R)-hydroxy(4-methoxyphenyl)methyl)-3-phenylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1345023-00-8
(2R,3S)-methyl 2-fluoro-2-(4-methoxybenzoyl)-3-phenylpentanoate

: 1345023-40-6
(2R,3S)-methyl 2-fluoro-2-((R)-hydroxy(4-methoxyphenyl)methyl)-3-phenylpentanoate

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; optical yield given as %de; diastereoselective reaction;
DOI:10.1002/anie.201104565

Reference yield:

: 1345023-22-4
C₁₈H₁₆O₄

: 1345023-40-6
(2R,3S)-methyl 2-fluoro-2-((R)-hydroxy(4-methoxyphenyl)methyl)-3-phenylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: C₆₄H₄₆NO₂P; copper(II) bis(trifluoromethanesulfonate) / hexane; toluene / 48 h / -40 °C / Inert atmosphere

2: N-fluorobenzenesulfonimide / hexane; toluene / 24 h / 20 °C / Inert atmosphere

3: sodium tetrahydroborate / methanol / 0 - 20 °C

With sodium tetrahydroborate; N-fluorobenzenesulfonimide; C₆₄H₄₆NO₂P; copper(II) bis(trifluoromethanesulfonate); In methanol; hexane; toluene;
DOI:10.1002/anie.201104565

Reference yield:

: 1345023-39-3
C₂₀H₂₂O₄

: 1345023-40-6
(2R,3S)-methyl 2-fluoro-2-((R)-hydroxy(4-methoxyphenyl)methyl)-3-phenylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-fluorobenzenesulfonimide / hexane; toluene / 24 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 0 - 20 °C

With sodium tetrahydroborate; N-fluorobenzenesulfonimide; In methanol; hexane; toluene;
DOI:10.1002/anie.201104565