benzyl 1-(4-(2-(1H-1,2,3-triazol-1-yl)ethyl)phenyl)piperidin-4-ylcarbamate

Base Information

Chemical Name:benzyl 1-(4-(2-(1H-1,2,3-triazol-1-yl)ethyl)phenyl)piperidin-4-ylcarbamate
CAS No.:1315251-49-0
Molecular Formula:C₂₃H₂₇N₅O₂
Molecular Weight:405.5
Hs Code.:

Synonyms:benzyl 1-(4-(2-(1H-1,2,3-triazol-1-yl)ethyl)phenyl)piperidin-4-ylcarbamate

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Chemical Property of benzyl 1-(4-(2-(1H-1,2,3-triazol-1-yl)ethyl)phenyl)piperidin-4-ylcarbamate

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Technology Process of benzyl 1-(4-(2-(1H-1,2,3-triazol-1-yl)ethyl)phenyl)piperidin-4-ylcarbamate

There total 9 articles about benzyl 1-(4-(2-(1H-1,2,3-triazol-1-yl)ethyl)phenyl)piperidin-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 288-36-8
1,2,3-triazole

: 1315251-47-8
4-(4-(benzyloxycarbonylamino)piperidin-1-yl)phenethyl 4-methylbenzenesulfonate

: 1315251-49-0
benzyl 1-(4-(2-(1H-1,2,3-triazol-1-yl)ethyl)phenyl)piperidin-4-ylcarbamate

Guidance literature:: at 90 ℃; for 2h;

Reference yield:

: 1315251-41-2
ethyl 4-(4-(benzyloxycarbonylamino)piperidin-1-yl)benzoate

: 1315251-49-0
benzyl 1-(4-(2-(1H-1,2,3-triazol-1-yl)ethyl)phenyl)piperidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / dichloromethane; hexane / 1 h / -78 °C

1.2: 21 h / 60 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / 0 °C

2.2: 17 h / 20 °C

3.1: hydrogenchloride / ethyl acetate; water / 1 h

3.2: 1 h / 0 °C

4.1: pyridine / 4 h / Cooling with ice

5.1: 2 h / 90 °C

With pyridine; hydrogenchloride; n-butyllithium; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; water; ethyl acetate;

Reference yield:

: 1315251-43-4
benzyl 1-(4-formylphenyl)piperidin-4-ylcarbamate

: 1315251-49-0
benzyl 1-(4-(2-(1H-1,2,3-triazol-1-yl)ethyl)phenyl)piperidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / 0 °C

1.2: 17 h / 20 °C

2.1: hydrogenchloride / ethyl acetate; water / 1 h

2.2: 1 h / 0 °C

3.1: pyridine / 4 h / Cooling with ice

4.1: 2 h / 90 °C

With pyridine; hydrogenchloride; n-butyllithium; In tetrahydrofuran; hexane; water; ethyl acetate;