[3-(3-amino-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl)-phenyl]-acetonitrile

Base Information

Chemical Name:[3-(3-amino-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl)-phenyl]-acetonitrile
CAS No.:796864-35-2
Molecular Formula:C₁₇H₁₇N₃O₂
Molecular Weight:295.341
Hs Code.:

Synonyms:[3-(3-amino-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl)-phenyl]-acetonitrile

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Chemical Property of [3-(3-amino-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl)-phenyl]-acetonitrile

Chemical Property:

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Technology Process of [3-(3-amino-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl)-phenyl]-acetonitrile

There total 8 articles about [3-(3-amino-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl)-phenyl]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 796864-33-0
N-[4-(3-cyanomethylbenzoyl)-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide

: 796864-35-2
[3-(3-amino-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl)-phenyl]-acetonitrile

Guidance literature:: With hydrogenchloride; for 2h; Heating;
DOI:10.1021/jm0407658

Reference yield:

: 68348-23-2
3-(1,3-dioxolan-2-yl)benzaldehyde

: 796864-35-2
[3-(3-amino-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl)-phenyl]-acetonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium; TMEDA / tetrahydrofuran; hexane / -78 - 0 °C

1.2: 69 percent / tetrahydrofuran; hexane / -78 - 0 °C

2.1: 73 percent / tri[2-(2-methoxyethoxy)ethyl]amine; KMnO₄ / CH₂Cl₂ / 12 h / 20 °C

3.1: 100 percent / aq. HCl / 1 h / 20 °C

4.1: 46 percent / sodium borohydride / methanol / 2 h / 5 °C

5.1: 100 percent / thionyl chloride / CH₂Cl₂ / 2 h / 5 - 20 °C

6.1: 72 percent / ethanol; H₂O / 2 h / 80 °C

7.1: 85 percent / aq. HCl / 2 h / Heating

With hydrogenchloride; sodium tetrahydroborate; potassium permanganate; n-butyllithium; thionyl chloride; N,N,N,N,-tetramethylethylenediamine; Tris(3,6-dioxaheptyl)amine; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water;
DOI:10.1021/jm0407658

Reference yield:

: 197229-98-4
5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridine

: 796864-35-2
[3-(3-amino-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl)-phenyl]-acetonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium; TMEDA / tetrahydrofuran; hexane / -78 - 0 °C

1.2: 69 percent / tetrahydrofuran; hexane / -78 - 0 °C

2.1: 73 percent / tri[2-(2-methoxyethoxy)ethyl]amine; KMnO₄ / CH₂Cl₂ / 12 h / 20 °C

3.1: 100 percent / aq. HCl / 1 h / 20 °C

4.1: 46 percent / sodium borohydride / methanol / 2 h / 5 °C

5.1: 100 percent / thionyl chloride / CH₂Cl₂ / 2 h / 5 - 20 °C

6.1: 72 percent / ethanol; H₂O / 2 h / 80 °C

7.1: 85 percent / aq. HCl / 2 h / Heating

With hydrogenchloride; sodium tetrahydroborate; potassium permanganate; n-butyllithium; thionyl chloride; N,N,N,N,-tetramethylethylenediamine; Tris(3,6-dioxaheptyl)amine; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water;
DOI:10.1021/jm0407658