5-[[4-[[2-(2-Pyridinyl)ethyl]thio]phenyl]methyl]-2,4-thiazolidinedione

Base Information

Chemical Name:5-[[4-[[2-(2-Pyridinyl)ethyl]thio]phenyl]methyl]-2,4-thiazolidinedione
CAS No.:136401-57-5
Molecular Formula:C₁₇H₁₆N₂O₂S₂
Molecular Weight:344.458
Hs Code.:
DSSTox Substance ID:DTXSID101155316
Nikkaji Number:J390.421K

Synonyms:DTXSID101155316;136401-57-5;5-[[4-[[2-(2-Pyridinyl)ethyl]thio]phenyl]methyl]-2,4-thiazolidinedione

Suppliers and Price of 5-[[4-[[2-(2-Pyridinyl)ethyl]thio]phenyl]methyl]-2,4-thiazolidinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[[4-[[2-(2-Pyridinyl)ethyl]thio]phenyl]methyl]-2,4-thiazolidinedione

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:344.06532010
Heavy Atom Count:23
Complexity:425

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=NC(=C1)CCSC2=CC=C(C=C2)CC3C(=O)NC(=O)S3

Technology Process of 5-[[4-[[2-(2-Pyridinyl)ethyl]thio]phenyl]methyl]-2,4-thiazolidinedione

There total 5 articles about 5-[[4-[[2-(2-Pyridinyl)ethyl]thio]phenyl]methyl]-2,4-thiazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 136401-78-0
2-imino-5-<4-<2-(2-pyridyl)ethylthio>benzyl>-4-thiazolidinone

: 136401-57-5
5-<4-<2-(2-Pyridyl)ethylthio>benzyl>-2,4-thiazolidinedione

Guidance literature:: With hydrogenchloride; In ethanol; for 16h; Heating;
DOI:10.1248/cpb.39.1440

Reference yield:

: 100-69-6,25014-15-7,27476-03-5,329041-71-6
2-vinylpyridine

: 136401-57-5
5-<4-<2-(2-Pyridyl)ethylthio>benzyl>-2,4-thiazolidinedione

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / 0.5 h / Ambient temperature

2: 1.) NaNO₂, aq. HBr / 2.) Cu₂O / 1.) H₂O, MeOH-acetone, 5 deg C, 30 min; 2.) 35 deg C

3: NaOCOCH₃ / ethanol / 2 h / Heating

4: 83 percent / 2 N HCl / ethanol / 16 h / Heating

With hydrogenchloride; hydrogen bromide; sodium acetate; sodium nitrite; copper(I) oxide; In ethanol;
DOI:10.1248/cpb.39.1440

Reference yield:

: 136401-56-4
4-<2-(2-pyridyl)ethylthio>aniline

: 136401-57-5
5-<4-<2-(2-Pyridyl)ethylthio>benzyl>-2,4-thiazolidinedione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaNO₂, aq. HBr / 2.) Cu₂O / 1.) H₂O, MeOH-acetone, 5 deg C, 30 min; 2.) 35 deg C

2: NaOCOCH₃ / ethanol / 2 h / Heating

3: 83 percent / 2 N HCl / ethanol / 16 h / Heating

With hydrogenchloride; hydrogen bromide; sodium acetate; sodium nitrite; copper(I) oxide; In ethanol;
DOI:10.1248/cpb.39.1440