4-[1-(1H-pyrrole-2-carbonyl)-pyrrolidin-3-yl]-3-trifluoromethyl-benzoic acid

Base Information

Chemical Name:4-[1-(1H-pyrrole-2-carbonyl)-pyrrolidin-3-yl]-3-trifluoromethyl-benzoic acid
CAS No.:1204331-75-8
Molecular Formula:C₁₇H₁₅F₃N₂O₃
Molecular Weight:352.313
Hs Code.:

Synonyms:4-[1-(1H-pyrrole-2-carbonyl)-pyrrolidin-3-yl]-3-trifluoromethyl-benzoic acid

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Chemical Property of 4-[1-(1H-pyrrole-2-carbonyl)-pyrrolidin-3-yl]-3-trifluoromethyl-benzoic acid

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Technology Process of 4-[1-(1H-pyrrole-2-carbonyl)-pyrrolidin-3-yl]-3-trifluoromethyl-benzoic acid

There total 4 articles about 4-[1-(1H-pyrrole-2-carbonyl)-pyrrolidin-3-yl]-3-trifluoromethyl-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1204331-74-7
4-[1-(1H-pyrrole-2-carbonyl)-pyrrolidin-3-yl]-3-trifluoromethyl-benzoic acid methyl ester

: 1204331-75-8
4-[1-(1H-pyrrole-2-carbonyl)-pyrrolidin-3-yl]-3-trifluoromethyl-benzoic acid

Guidance literature:: 4-[1-(1H-pyrrole-2-carbonyl)-pyrrolidin-3-yl]-3-trifluoromethyl-benzoic acid methyl ester; With lithium hydroxide monohydrate; for 16h;

With citric acid; In water;

Reference yield:

: 1204331-70-3
3-(4-cyano-2-trifluoromethyl-phenyl)-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

: 1204331-75-8
4-[1-(1H-pyrrole-2-carbonyl)-pyrrolidin-3-yl]-3-trifluoromethyl-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: water; sodium hydroxide / ethanol / 2 h / Reflux

2: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 3102.97 Torr

3: hydrogenchloride / 16 h

4: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0 - 20 °C

5: lithium hydroxide monohydrate / 16 h

With hydrogenchloride; lithium hydroxide monohydrate; water; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol;

Reference yield:

: 1204331-71-4
3-(4-carboxy-2-trifluoromethyl-phenyl)-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

: 1204331-75-8
4-[1-(1H-pyrrole-2-carbonyl)-pyrrolidin-3-yl]-3-trifluoromethyl-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 3102.97 Torr

2: hydrogenchloride / 16 h

3: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0 - 20 °C

4: lithium hydroxide monohydrate / 16 h

With hydrogenchloride; lithium hydroxide monohydrate; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; methanol;