Benzenemethanamine, a-methyl-4-(trifluoromethoxy)-, (aS)-

Base Information

• Chemical Name: Benzenemethanamine, a-methyl-4-(trifluoromethoxy)-, (aS)-
• CAS No.: 951247-75-9
• Molecular Formula: C₉H₁₀F₃NO
• Molecular Weight: 205.18
• Hs Code.: 2921490090
• Mol file: 951247-75-9.mol

Synonyms:S01-0750;Benzenemethanamine,a-methyl-4-(trifluoromethoxy)-,(aS);(S)-1-(4-(Trifluoromethoxy)phenyl)ethanamine;

Chemical Property of Benzenemethanamine, a-methyl-4-(trifluoromethoxy)-, (aS)-

Chemical Property:

• PSA: 35.25000
• LogP: 3.30520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(S)-1-(4-(Trifluoromethoxy)phenyl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanamine, a-methyl-4-(trifluoromethoxy)-, (aS)-

There total 5 articles about Benzenemethanamine, a-methyl-4-(trifluoromethoxy)-, (aS)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-[4-(trifluoromethoxy)phenyl]ethan-1-one (85013-98-5) → 1-[4-(trifluoromethoxy)phenyl]ethylamine (1209050-26-9,123195-23-3,951247-75-9)

Guidance literature:

With nickel(II) tetrafluoroborate hexahydrate; ammonia; hydrogen; bis(2-diphenylphosphinoethyl)phenylphosphine; In 2,2,2-trifluoroethanol; at 120 ℃; for 24h; chemoselective reaction;

DOI:10.1039/d0sc01084g

Reference yield: 80.0%

(R)-2-methyl-N-((S)-1-(4-(trifluoromethoxy)phenyl)ethyl)propane-2-sulfinamide → (1S)-1-[4-(trifluoromethoxy)phenyl]ethylamine (1209050-26-9,123195-23-3,951247-75-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

(1R,1'R)-N-(1'-phenylethyl)-1-(4''-trifluoromethoxyphenyl)-ethylamine → (R)-1-(4-Trifluoromethoxy-phenyl)-ethylamine (1209050-26-9,123195-23-3,951247-75-9)

Guidance literature:

With ammonium formate; 10percent Pd/C; In methanol; for 2h; Heating;

DOI:10.1021/jm9905099

upstream raw materials:

1-[4-(trifluoromethoxy)phenyl]ethan-1-one

p-trifluoromethoxybenzaldehyde

Refernces

• 1、 -. "3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH". . . Retrieved 2014/09/29.
• 2、 Butera, John A.,Antane, Madelene M.,Antane, Schuyler A.,Argentieri, Thomas M.,Freeden, Chris,Graceffa, Russell F.,Hirth, Bradford H.,Jenkins, Douglas,Lennox, Joseph R.,Matelan, Edward,Norton, N. Wesley,Quagliato, Dominick,Sheldon, Jeffrey H.,Spinelli, Walter,Warga, Dawn,Wojdan, Alexandra,Woods, Morgan. "Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 1. N-cyanoguanidine bioisosteres possessing in vive bladder selectivity". . p. 1187 - 1202. Retrieved 2007/10/03.