(S)-1,3,4,9-Tetrahydro-β-carboline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester

Base Information

Chemical Name:(S)-1,3,4,9-Tetrahydro-β-carboline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester
CAS No.:160024-55-5
Molecular Formula:C₂₁H₂₀N₂O₄
Molecular Weight:364.401
Hs Code.:

Synonyms:(S)-1,3,4,9-Tetrahydro-β-carboline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1,3,4,9-Tetrahydro-β-carboline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester

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Technology Process of (S)-1,3,4,9-Tetrahydro-β-carboline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester

There total 2 articles about (S)-1,3,4,9-Tetrahydro-β-carboline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 79815-18-2
methyl (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylate

: 160024-55-5
(S)-1,3,4,9-Tetrahydro-β-carboline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester

Guidance literature:: In dichloromethane; at -10 ℃; for 0.25h;
DOI:10.1016/S0957-4166(00)86273-4

Reference yield:

: 7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8
(S)-tryptophan methyl ester hydrochloride

: 160024-55-5
(S)-1,3,4,9-Tetrahydro-β-carboline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / methanol; H₂O / 4 h / 20 °C

2: 63 percent / Et₃N / tetrahydrofuran / Heating

With triethylamine; In tetrahydrofuran; methanol; water; 1: Pictet-Spengler cyclization;
DOI:10.1016/S0968-0896(01)00042-6