<1S^,2R^,4S^,(S)R^>-4-(1,1-dimethylethyl)-2-(phenylsulfinyl)cyclohexanol

Base Information

Chemical Name:<1S^*,2R^*,4S^*,(S)R^*>-4-(1,1-dimethylethyl)-2-(phenylsulfinyl)cyclohexanol
CAS No.:124992-60-5
Molecular Formula:C₁₆H₂₄O₂S
Molecular Weight:280.431
Hs Code.:

<1S<sup>*</sup>,2R<sup>*</sup>,4S<sup>*</sup>,(S)R<sup>*</sup>>-4-(1,1-dimethylethyl)-2-(phenylsulfinyl)cyclohexanol

Synonyms:<1S^*,2R^*,4S^*,(S)R^*>-4-(1,1-dimethylethyl)-2-(phenylsulfinyl)cyclohexanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of <1S^*,2R^*,4S^*,(S)R^*>-4-(1,1-dimethylethyl)-2-(phenylsulfinyl)cyclohexanol

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Technology Process of <1S^*,2R^*,4S^*,(S)R^*>-4-(1,1-dimethylethyl)-2-(phenylsulfinyl)cyclohexanol

There total 3 articles about <1S^*,2R^*,4S^*,(S)R^*>-4-(1,1-dimethylethyl)-2-(phenylsulfinyl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 125074-81-9
<2R^*,4S^*,(S)R^*>-4,4-(1-dimethylethyl)-2-(methylsulfinyl)cyclohexanone

: 124992-60-5
<1S^*,2R^*,4S^*,(S)R^*>-4-(1,1-dimethylethyl)-2-(phenylsulfinyl)cyclohexanol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1021/jo00294a027

Reference yield:

: 125074-81-9
<2R^*,4S^*,(S)R^*>-4,4-(1-dimethylethyl)-2-(methylsulfinyl)cyclohexanone

: 124992-60-5
<1S^*,2R^*,4S^*,(S)R^*>-4-(1,1-dimethylethyl)-2-(phenylsulfinyl)cyclohexanol

: 125074-93-3
<1R^*,2R^*,4S^*,(S)R^*>-4-(1,1-dimethylethyl)-2-(phenylsulfinyl)cyclohexanol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃; for 1h; Yield given. Yields of byproduct given;
DOI:10.1021/jo00294a027

Reference yield:

: 60774-46-1,63608-45-7,73843-08-0,145929-90-4,145929-91-5
trans-4-(1,1-dimethylethyl)-2-(methylthio)cyclohexanone

: 124992-60-5
<1S^*,2R^*,4S^*,(S)R^*>-4-(1,1-dimethylethyl)-2-(phenylsulfinyl)cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: m-chloroperbenzoic acid / CHCl₃ / 0.25 h / Ambient temperature

2: 81 percent / NaBH₄ / tetrahydrofuran / 1 h / -78 °C

With sodium tetrahydroborate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform;
DOI:10.1021/jo00294a027