N⁴-acetyl-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}cytosine

Base Information

• Chemical Name: N⁴-acetyl-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}cytosine
• CAS No.: 1431298-67-7
• Molecular Formula: C₄₁H₄₀N₄O₇
• Molecular Weight: 700.791

Synonyms:N⁴-acetyl-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}cytosine

Chemical Property of N⁴-acetyl-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}cytosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-acetyl-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}cytosine

There total 4 articles about N⁴-acetyl-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}cytosine (1431298-66-6) + acetic anhydride (108-24-7) → N4-acetyl-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}cytosine (1431298-67-7)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 20h;

DOI:10.1016/j.tet.2013.03.054

Reference yield:

tripopargylamine (6921-29-5) → N4-acetyl-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}cytosine (1431298-67-7)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2: pyridine / 8 h / 20 °C

3: N,N-dimethyl-formamide / 20 h / 20 °C

With pyridine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;

DOI:10.1016/j.tet.2013.03.054

Reference yield:

1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}cytosine (1431298-65-5) → N4-acetyl-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}cytosine (1431298-67-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 8 h / 20 °C

2: N,N-dimethyl-formamide / 20 h / 20 °C

With pyridine; In N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2013.03.054

upstream raw materials:

tripopargylamine

1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}cytosine

1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}cytosine

acetic anhydride

Downstream raw materials:

N⁴-acetyl-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}-cytosine 3'-(2-cyanoethyl)-N,N'-diisopropyl phosphoramidite

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1431298-67-7 N⁴-acetyl-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}cytosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send