ethyl (2R)-2-benzyl-3-[(3,5-dimethoxybenzyl)amino]-2-hydroxy-3-oxopropanoate

Base Information

Chemical Name:ethyl (2R)-2-benzyl-3-[(3,5-dimethoxybenzyl)amino]-2-hydroxy-3-oxopropanoate
CAS No.:1430104-92-9
Molecular Formula:C₂₁H₂₅NO₆
Molecular Weight:387.433
Hs Code.:

Synonyms:ethyl (2R)-2-benzyl-3-[(3,5-dimethoxybenzyl)amino]-2-hydroxy-3-oxopropanoate

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Chemical Property of ethyl (2R)-2-benzyl-3-[(3,5-dimethoxybenzyl)amino]-2-hydroxy-3-oxopropanoate

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Technology Process of ethyl (2R)-2-benzyl-3-[(3,5-dimethoxybenzyl)amino]-2-hydroxy-3-oxopropanoate

There total 4 articles about ethyl (2R)-2-benzyl-3-[(3,5-dimethoxybenzyl)amino]-2-hydroxy-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 34967-24-3
3,5-dimethoxybenzylamine

: 1430104-90-7
(2R)-2-benzyl-3-ethoxy-2-hydroxy-3-oxopropanoic acid

: 1430104-92-9
ethyl (2R)-2-benzyl-3-[(3,5-dimethoxybenzyl)amino]-2-hydroxy-3-oxopropanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2013.05.077

Reference yield:

: 56150-08-4
diethyl α-benzyl α-hydroxymalonate

: 1430104-92-9
ethyl (2R)-2-benzyl-3-[(3,5-dimethoxybenzyl)amino]-2-hydroxy-3-oxopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol / 20 °C

1.2: pH 2

2.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 607-81-8
diethyl 2-benzylmalonate

: 1430104-92-9
ethyl (2R)-2-benzyl-3-[(3,5-dimethoxybenzyl)amino]-2-hydroxy-3-oxopropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: cesium fluoride; oxygen / N,N-dimethyl-formamide / 72 h / 40 °C

2.1: potassium hydroxide / ethanol / 20 °C

2.2: pH 2

3.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With oxygen; N-ethyl-N,N-diisopropylamine; cesium fluoride; HATU; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;