3-Cyano-2-(dimethylamino-methyleneamino)-6,7-dihydro-5H-pyrrolizine-1-carboxylic acid ethyl ester

Base Information

Chemical Name:3-Cyano-2-(dimethylamino-methyleneamino)-6,7-dihydro-5H-pyrrolizine-1-carboxylic acid ethyl ester
CAS No.:111038-15-4
Molecular Formula:C₁₄H₁₈N₄O₂
Molecular Weight:274.323
Hs Code.:

Synonyms:3-Cyano-2-(dimethylamino-methyleneamino)-6,7-dihydro-5H-pyrrolizine-1-carboxylic acid ethyl ester

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Chemical Property of 3-Cyano-2-(dimethylamino-methyleneamino)-6,7-dihydro-5H-pyrrolizine-1-carboxylic acid ethyl ester

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Technology Process of 3-Cyano-2-(dimethylamino-methyleneamino)-6,7-dihydro-5H-pyrrolizine-1-carboxylic acid ethyl ester

There total 4 articles about 3-Cyano-2-(dimethylamino-methyleneamino)-6,7-dihydro-5H-pyrrolizine-1-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 106345-07-7
1,2-dihydro-3H-5-cyano-6-amino-7-ethoxycarbonylpyrrolo<1,2-a>pyrrole

: 1188-33-6
N,N-dimethylformamide diethyl diacetal

: 111038-15-4,1164491-24-0
5-Cyano-6-(N,N-dimethylaminomethylene)amino-7-ethoxycarbonyl-1,2-dihydro-3H-pyrrolizine

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 0.5h;
DOI:10.1007/BF00757481

Reference yield:

: 115997-20-1
1-Cyanomethyl-2-(2'-cyano-2'-ethoxycarbonyl)methylenepyrrolidine

: 111038-15-4,1164491-24-0
5-Cyano-6-(N,N-dimethylaminomethylene)amino-7-ethoxycarbonyl-1,2-dihydro-3H-pyrrolizine

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / sodium tert-butylate / 2-methyl-propan-2-ol / 4 h / Heating

2: 94 percent / dimethylformamide / 0.5 h / 100 °C

With sodium t-butanolate; In N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1007/BF00757481

Reference yield:

: 91417-88-8
diethylacetal of N-cyanomethyl-2-pyrrolidone

: 111038-15-4,1164491-24-0
5-Cyano-6-(N,N-dimethylaminomethylene)amino-7-ethoxycarbonyl-1,2-dihydro-3H-pyrrolizine

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / 2 h / 5 - 7 °C

2: 92 percent / sodium tert-butylate / 2-methyl-propan-2-ol / 4 h / Heating

3: 94 percent / dimethylformamide / 0.5 h / 100 °C

With sodium t-butanolate; In N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1007/BF00757481