Technology Process of 5-benzyl-1-(3-phenylpropyl)-1H-imidazol-2-amine hydrochloride
There total 9 articles about 5-benzyl-1-(3-phenylpropyl)-1H-imidazol-2-amine hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
2: CYANAMID; sodium hydroxide / ethanol; water / 3 h / 95 °C / pH 4.3
3: hydrogenchloride / methanol; water
With
hydrogenchloride; CYANAMID; trifluoroacetic acid; sodium hydroxide;
In
methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2011.05.123
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: lithium hydroxide monohydrate / methanol / 0.33 h / 20 °C
1.2: 1 h
2.1: sodium tetrahydroborate / methanol / 0.5 h
3.1: tetra(n-butyl)ammonium hydroxide / acetonitrile / 0.5 h / 20 °C
3.2: 18 h / 20 °C
4.1: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 0.25 h / 20 °C / Inert atmosphere
4.2: 18 h / 20 °C / Inert atmosphere
5.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere
6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
7.1: CYANAMID; sodium hydroxide / ethanol; water / 3 h / 95 °C / pH 4.3
8.1: hydrogenchloride / methanol; water
With
hydrogenchloride; sodium tetrahydroborate; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; lithium hydroxide monohydrate; CYANAMID; tetra(n-butyl)ammonium hydroxide; diisobutylaluminium hydride; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmcl.2011.05.123
