(4-chlorophenyl)(1-methyl-1H-1,2,3-benzotriazol-5-yl)methanol

Base Information

• Chemical Name: (4-chlorophenyl)(1-methyl-1H-1,2,3-benzotriazol-5-yl)methanol
• CAS No.: 120322-04-5
• Molecular Formula: C₁₄H₁₂ClN₃O
• Molecular Weight: 273.722
• Mol file: 120322-04-5.mol

Synonyms:(4-chlorophenyl)(1-methyl-1H-1,2,3-benzotriazol-5-yl)methanol

Chemical Property of (4-chlorophenyl)(1-methyl-1H-1,2,3-benzotriazol-5-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-chlorophenyl)(1-methyl-1H-1,2,3-benzotriazol-5-yl)methanol

There total 12 articles about (4-chlorophenyl)(1-methyl-1H-1,2,3-benzotriazol-5-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-methyl-1H-benzo[d][1,2,3]triazole-5-carbaldehyde (499770-67-1) + (4-chlorphenyl)magnesium bromide (873-77-8) → (4-chlorophenyl)(1-methyl-1H-1,2,3-benzotriazol-5-yl)methanol (120322-04-5)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b00228

Reference yield:

5-(1,3-dioxolan-2-yl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((trimethylsilyl)methyl)-1H-benzo[d]triazole (1426579-74-9) → (4-chlorophenyl)(1-methyl-1H-1,2,3-benzotriazol-5-yl)methanol (120322-04-5)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; potassium fluoride / methanol / 48 h / 70 °C / Inert atmosphere; Microwave irradiation

2: toluene-4-sulfonic acid / acetone / 9 h / 20 °C

3: diethyl ether / 1 h / -78 °C / Inert atmosphere

With potassium fluoride; palladium 10% on activated carbon; toluene-4-sulfonic acid; In methanol; diethyl ether; acetone;

DOI:10.1021/jo302802b

Reference yield:

4-(1,3-dioxolan-2-yl)-2-iodo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl 2,4,5-trichlorobenzenesulfonate (1426579-79-4) → (4-chlorophenyl)(1-methyl-1H-1,2,3-benzotriazol-5-yl)methanol (120322-04-5)

Guidance literature:

Multi-step reaction with 4 steps

1: TurboGrignard / diethyl ether; tetrahydrofuran / 1.08 h / -78 - 0 °C / Inert atmosphere

2: palladium 10% on activated carbon; potassium fluoride / methanol / 48 h / 70 °C / Inert atmosphere; Microwave irradiation

3: toluene-4-sulfonic acid / acetone / 9 h / 20 °C

4: diethyl ether / 1 h / -78 °C / Inert atmosphere

With potassium fluoride; TurboGrignard; palladium 10% on activated carbon; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; acetone;

DOI:10.1021/jo302802b

upstream raw materials:

5-(1,3-dioxolan-2-yl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((trimethylsilyl)methyl)-1H-benzo[d]triazole

4-(1,3-dioxolan-2-yl)-2-iodo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl 2,4,5-trichlorobenzenesulfonate

5-(1,3-dioxolan-2-yl)-1-methyl-1H-benzo[d]triazole

1-methyl-1H-benzo[d][1,2,3]triazole-5-carbaldehyde

Downstream raw materials:

5-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl)-1-methyl-1H-benzo[d]triazole