2,5-difluoro-N-[2-fluoro-3-(1-oxetan-3-yl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenyl]benzenesulfonamide

Base Information

• Chemical Name: 2,5-difluoro-N-[2-fluoro-3-(1-oxetan-3-yl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenyl]benzenesulfonamide
• CAS No.: 1357587-29-1
• Molecular Formula: C₂₃H₁₇F₃N₄O₃S
• Molecular Weight: 486.474
• Mol file: 1357587-29-1.mol

Synonyms:2,5-difluoro-N-[2-fluoro-3-(1-oxetan-3-yl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenyl]benzenesulfonamide

Chemical Property of 2,5-difluoro-N-[2-fluoro-3-(1-oxetan-3-yl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenyl]benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-difluoro-N-[2-fluoro-3-(1-oxetan-3-yl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenyl]benzenesulfonamide

There total 4 articles about 2,5-difluoro-N-[2-fluoro-3-(1-oxetan-3-yl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxetan-3-yl trifluoromethanesulfonate (1379585-89-3) + 2,5-difluoro-N-[2-fluoro-3-(4-pyridin-4-yl-1H-pyrazol-3-yl)phenyl]benzenesulfonamide (1357587-28-0) → 2,5-difluoro-N-{2-fluoro-3-[1-(oxetan-2-yl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}benzenesulfonamide (1357587-30-4) + 2,5-difluoro-N-[2-fluoro-3-(1-oxetan-3-yl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenyl]benzenesulfonamide (1357587-29-1)

Guidance literature:

2,5-difluoro-N-[2-fluoro-3-(4-pyridin-4-yl-1H-pyrazol-3-yl)phenyl]benzenesulfonamide; With sodium hydride; In hexane; N,N-dimethyl-formamide; at 0 ℃; for 0.666667h; Inert atmosphere;

oxetan-3-yl trifluoromethanesulfonate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

N-{3-[4-bromo-1-(tetrahydropyran-2-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide (1357587-80-4) → 2,5-difluoro-N-{2-fluoro-3-[1-(oxetan-2-yl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}benzenesulfonamide (1357587-30-4) + 2,5-difluoro-N-[2-fluoro-3-(1-oxetan-3-yl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenyl]benzenesulfonamide (1357587-29-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.75 h / 100 °C / Inert atmosphere; Microwave irradiation

2.1: trifluoroacetic acid / water / 2 h / 60 °C

3.1: sodium hydride / N,N-dimethyl-formamide; hexane / 0.67 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C

With sodium hydride; caesium carbonate; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; hexane; water; N,N-dimethyl-formamide;

Reference yield:

C22H22F3N3O4S → 2,5-difluoro-N-{2-fluoro-3-[1-(oxetan-2-yl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}benzenesulfonamide (1357587-30-4) + 2,5-difluoro-N-[2-fluoro-3-(1-oxetan-3-yl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenyl]benzenesulfonamide (1357587-29-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / dichloromethane / 4 h / 20 °C

2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.75 h / 100 °C / Inert atmosphere; Microwave irradiation

3.1: trifluoroacetic acid / water / 2 h / 60 °C

4.1: sodium hydride / N,N-dimethyl-formamide; hexane / 0.67 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C

With N-Bromosuccinimide; sodium hydride; caesium carbonate; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; hexane; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

N-{3-[4-bromo-1-(tetrahydropyran-2-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide

2,5-difluoro-N-{2-fluoro-3-[4-pyridin-4-yl-1-(tetrahydropyran-2-yl)-1H-pyrazol-3-yl]phenyl}-N-methoxymethylbenzenesulfonamide

oxetan-3-yl trifluoromethanesulfonate

2,5-difluoro-N-[2-fluoro-3-(4-pyridin-4-yl-1H-pyrazol-3-yl)phenyl]benzenesulfonamide