(4bS,8aS)-4b,5,6,7,8,8a,9,10-Octahydro-1,4-dihydroxy-4b,8,8-trimethyl-2-phenanthrenecarbaldehyde

Base Information

Chemical Name:(4bS,8aS)-4b,5,6,7,8,8a,9,10-Octahydro-1,4-dihydroxy-4b,8,8-trimethyl-2-phenanthrenecarbaldehyde
CAS No.:68042-46-6
Molecular Formula:C₁₈H₂₄O₃
Molecular Weight:288.387
Hs Code.:
Mol file:68042-46-6.mol

Synonyms:2-Phenanthrenecarboxaldehyde,4b,5,6,7,8,8a,9,10-octahydro-3,4-dihydroxy-4b,8,8-trimethyl-, (4bS-trans)-;(+)-Premnolal; Premnolal

Suppliers and Price of (4bS,8aS)-4b,5,6,7,8,8a,9,10-Octahydro-1,4-dihydroxy-4b,8,8-trimethyl-2-phenanthrenecarbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4bS,8aS)-4b,5,6,7,8,8a,9,10-Octahydro-1,4-dihydroxy-4b,8,8-trimethyl-2-phenanthrenecarbaldehyde

Chemical Property:

PSA：57.53000
LogP:3.94050

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (4bS,8aS)-4b,5,6,7,8,8a,9,10-Octahydro-1,4-dihydroxy-4b,8,8-trimethyl-2-phenanthrenecarbaldehyde

There total 18 articles about (4bS,8aS)-4b,5,6,7,8,8a,9,10-Octahydro-1,4-dihydroxy-4b,8,8-trimethyl-2-phenanthrenecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 85853-05-0
11,12-dimethoxypodocarpa-8,11,13-triene-13-carbaldehyde

: 68042-46-6
premnolal

Guidance literature:: With aluminium trichloride; In dichloromethane; for 6h; Heating;
DOI:10.1246/bcsj.56.290

Reference yield:

: 10064-08-1
(+)-(5S,10S)-12-methoxypodocarpa-8,11,13-triene

: 68042-46-6
premnolal

Guidance literature:: Multi-step reaction with 12 steps

1: 83 percent / boron tribromide / CH₂Cl₂ / 1 h / 5 - 10 °C

2: 12 percent / acetic acid / 0.5 h / Heating

3: lithium aluminium hydride / diethyl ether / 1.5 h / Ambient temperature

4: 0.08 h / Heating

5: 294 mg / nitric acid, acetic anhydride / 0.5 h / -10 - -7 °C

6: 478 mg / potassium carbonate / butan-2-one / 5 h / Heating

7: H₂ / PtO₂ / ethanol / 3 h / Ambient temperature

8: 1.) sodium nitrite, 2percent aq. sulfuric acid, 2.) water / 1.) THF, from -10 deg C to -7 deg C, 30 min, 2.) from 80 deg C to 90 deg C, 5 min

9: lithium aluminium hydride / diethyl ether / 1.5 h / Ambient temperature

10: 74 percent / potassium carbonate / butan-2-one / 10 h / Heating

11: 83 percent / barium manganate / CH₂Cl₂ / 24 h / Ambient temperature

12: 88 percent / aluminium chloride / CH₂Cl₂ / 6 h / Heating

With lithium aluminium tetrahydride; aluminium trichloride; barium manganate; sulfuric acid; water; hydrogen; nitric acid; acetic anhydride; boron tribromide; potassium carbonate; acetic acid; sodium nitrite; platinum(IV) oxide; In diethyl ether; ethanol; dichloromethane; butanone;
DOI:10.1246/bcsj.56.290

Reference yield:

: 1224-26-6
12-methoxypodocarpa-8,11,13-trien-18-ol

: 68042-46-6
premnolal

Guidance literature:: Multi-step reaction with 14 steps

1: pyridine / 3 h / 80 - 90 °C

2: sodium iodide, Zn / dimethylformamide / 6 h / 110 - 115 °C

3: 83 percent / boron tribromide / CH₂Cl₂ / 1 h / 5 - 10 °C

4: 12 percent / acetic acid / 0.5 h / Heating

5: lithium aluminium hydride / diethyl ether / 1.5 h / Ambient temperature

6: 0.08 h / Heating

7: 294 mg / nitric acid, acetic anhydride / 0.5 h / -10 - -7 °C

8: 478 mg / potassium carbonate / butan-2-one / 5 h / Heating

9: H₂ / PtO₂ / ethanol / 3 h / Ambient temperature

10: 1.) sodium nitrite, 2percent aq. sulfuric acid, 2.) water / 1.) THF, from -10 deg C to -7 deg C, 30 min, 2.) from 80 deg C to 90 deg C, 5 min

11: lithium aluminium hydride / diethyl ether / 1.5 h / Ambient temperature

12: 74 percent / potassium carbonate / butan-2-one / 10 h / Heating

13: 83 percent / barium manganate / CH₂Cl₂ / 24 h / Ambient temperature

14: 88 percent / aluminium chloride / CH₂Cl₂ / 6 h / Heating

With pyridine; lithium aluminium tetrahydride; aluminium trichloride; barium manganate; sulfuric acid; water; hydrogen; nitric acid; acetic anhydride; boron tribromide; potassium carbonate; acetic acid; sodium iodide; zinc; sodium nitrite; platinum(IV) oxide; In diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; butanone;
DOI:10.1246/bcsj.56.290