N₁,N₇-bis(3-bromomethylphenyl)-4-(3-(3-bromomethylphenylamino)-3-oxopropyl)-4-(3,4-dihydroxybenzamido)heptanediamide

Base Information

• Chemical Name: N₁,N₇-bis(3-bromomethylphenyl)-4-(3-(3-bromomethylphenylamino)-3-oxopropyl)-4-(3,4-dihydroxybenzamido)heptanediamide
• CAS No.: 1260095-67-7
• Molecular Formula: C₃₈H₃₉Br₃N₄O₆
• Molecular Weight: 887.463
• Mol file: 1260095-67-7.mol

Synonyms:N₁,N₇-bis(3-bromomethylphenyl)-4-(3-(3-bromomethylphenylamino)-3-oxopropyl)-4-(3,4-dihydroxybenzamido)heptanediamide

Chemical Property of N₁,N₇-bis(3-bromomethylphenyl)-4-(3-(3-bromomethylphenylamino)-3-oxopropyl)-4-(3,4-dihydroxybenzamido)heptanediamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁,N₇-bis(3-bromomethylphenyl)-4-(3-(3-bromomethylphenylamino)-3-oxopropyl)-4-(3,4-dihydroxybenzamido)heptanediamide

There total 4 articles about N₁,N₇-bis(3-bromomethylphenyl)-4-(3-(3-bromomethylphenylamino)-3-oxopropyl)-4-(3,4-dihydroxybenzamido)heptanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamido)-N1,N7-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide (1260095-63-3) → N1,N7-bis(3-bromomethylphenyl)-4-(3-(3-bromomethylphenylamino)-3-oxopropyl)-4-(3,4-dihydroxybenzamido)heptanediamide (1260095-67-7)

Guidance literature:

4-(2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamido)-N₁,N₇-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide; With hydrogen bromide; acetic acid; In dichloromethane; at 20 ℃;

With water; sodium hydrogencarbonate; In dichloromethane; pH=7;

DOI:10.1021/ja106076h

Reference yield:

4-amino-N1,N7-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide (1260095-59-7) → N1,N7-bis(3-bromomethylphenyl)-4-(3-(3-bromomethylphenylamino)-3-oxopropyl)-4-(3,4-dihydroxybenzamido)heptanediamide (1260095-67-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 48 h / 20 °C

2.1: hydrogen bromide; acetic acid / dichloromethane / 20 °C

2.2: pH 7

With hydrogen bromide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja106076h

Reference yield:

9H-fluoren-9-ylmethyl 1,7-bis(3-methoxymethylphenylamino)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)-1,7-dioxoheptan-4-ylcarbamate (1260095-55-3) → N1,N7-bis(3-bromomethylphenyl)-4-(3-(3-bromomethylphenylamino)-3-oxopropyl)-4-(3,4-dihydroxybenzamido)heptanediamide (1260095-67-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: piperidine / N,N-dimethyl-formamide / 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 0 °C

2.2: 48 h / 20 °C

3.1: hydrogen bromide; acetic acid / dichloromethane / 20 °C

3.2: pH 7

With piperidine; hydrogen bromide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja106076h

upstream raw materials:

9H-fluoren-9-ylmethyl 1,7-bis(3-methoxymethylphenylamino)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)-1,7-dioxoheptan-4-ylcarbamate

N₁,N₇-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)-4-nitroheptanediamide

4-amino-N₁,N₇-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide

4-(2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamido)-N₁,N₇-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide