2-[3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-propoxy]-4-methoxy-5-thien-2-yl-benzaldehyde

Base Information

Chemical Name:2-[3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-propoxy]-4-methoxy-5-thien-2-yl-benzaldehyde
CAS No.:552846-05-6
Molecular Formula:C₂₈H₄₆O₅SSi₂
Molecular Weight:550.907
Hs Code.:

Synonyms:2-[3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-propoxy]-4-methoxy-5-thien-2-yl-benzaldehyde

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Chemical Property of 2-[3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-propoxy]-4-methoxy-5-thien-2-yl-benzaldehyde

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Technology Process of 2-[3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-propoxy]-4-methoxy-5-thien-2-yl-benzaldehyde

There total 4 articles about 2-[3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-propoxy]-4-methoxy-5-thien-2-yl-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 552845-71-3
2-hydroxy-4-methoxy-5-thien-2-yl-benzaldehyde

: 201337-14-6
methanesulfonic acid 3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-propyl ester

: 552846-05-6
2-[3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-propoxy]-4-methoxy-5-thien-2-yl-benzaldehyde

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 24h;
DOI:10.1021/jm0614230

Reference yield:

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

: 552846-05-6
2-[3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-propoxy]-4-methoxy-5-thien-2-yl-benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / Br₂ / CH₂Cl₂ / 3 h / 0 - 20 °C

2: 97 percent / KF / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 1.5 h / 60 °C

3: 81 percent / K₂CO₃ / dimethylformamide / 24 h / 80 °C

With potassium fluoride; bromine; potassium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1021/jm0614230

Reference yield:

: 57543-36-9
5-bromo-2-hydroxy-4-methoxybenzaldehyde

: 552846-05-6
2-[3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-propoxy]-4-methoxy-5-thien-2-yl-benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / KF / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 1.5 h / 60 °C

2: 81 percent / K₂CO₃ / dimethylformamide / 24 h / 80 °C

With potassium fluoride; potassium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1021/jm0614230