(3aR,4aS,5R,6S,8aR,8bR)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-hydroxy-2,2,5-trimethyl-hexahydro-benzo[4,5]furo[2,3-d][1,3]dioxol-7-one

Base Information

Chemical Name:(3aR,4aS,5R,6S,8aR,8bR)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-hydroxy-2,2,5-trimethyl-hexahydro-benzo[4,5]furo[2,3-d][1,3]dioxol-7-one
CAS No.:143135-24-4
Molecular Formula:C₃₀H₄₀O₆Si
Molecular Weight:524.73
Hs Code.:

Synonyms:(3aR,4aS,5R,6S,8aR,8bR)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-hydroxy-2,2,5-trimethyl-hexahydro-benzo[4,5]furo[2,3-d][1,3]dioxol-7-one

Suppliers and Price of (3aR,4aS,5R,6S,8aR,8bR)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-hydroxy-2,2,5-trimethyl-hexahydro-benzo[4,5]furo[2,3-d][1,3]dioxol-7-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3aR,4aS,5R,6S,8aR,8bR)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-hydroxy-2,2,5-trimethyl-hexahydro-benzo[4,5]furo[2,3-d][1,3]dioxol-7-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3aR,4aS,5R,6S,8aR,8bR)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-hydroxy-2,2,5-trimethyl-hexahydro-benzo[4,5]furo[2,3-d][1,3]dioxol-7-one

There total 9 articles about (3aR,4aS,5R,6S,8aR,8bR)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-hydroxy-2,2,5-trimethyl-hexahydro-benzo[4,5]furo[2,3-d][1,3]dioxol-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 143135-33-5
3,6-Dideoxy-1,2-O-isopropylidene-3-C-<2-oxo-5-<(tert-butyldiphenylsilyl)oxy>pentyl>-α-D-allofuran-5-ulose

: 143135-24-4
(3aR,4aS,5R,6S,8aR,8bR)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-hydroxy-2,2,5-trimethyl-hexahydro-benzo[4,5]furo[2,3-d][1,3]dioxol-7-one

Guidance literature:: With potassium tert-butylate; In benzene; at 0 ℃; for 0.5h;
DOI:10.1016/S0040-4020(01)80440-3

Reference yield:

: 18427-19-5
1,2;5,6-di-O-isopropylidene-3-(2-hydroxyethyl)-α-D-allofuranoside

: 143135-24-4
(3aR,4aS,5R,6S,8aR,8bR)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-hydroxy-2,2,5-trimethyl-hexahydro-benzo[4,5]furo[2,3-d][1,3]dioxol-7-one

Guidance literature:: Multi-step reaction with 9 steps

1: PCC, molecular sieves 4A / CH₂Cl₂ / 0.75 h

2: 87 percent / tetrahydrofuran / 0.75 h / Ambient temperature

3: 1) BH₃*THF, 2) 35percent aq. H₂O₂, 3M aq. NaOH / 1) THF, 0 deg C, 3h, 2) water, 30 min

4: imidazole / dimethylformamide / 3 h

5: 64 percent / AcOH / tetrahydrofuran; H₂O / 15 h

6: 681 mg / NaIO₄ / methanol; H₂O / 1 h

7: 731 mg / tetrahydrofuran / 0.5 h / Heating

8: 558 mg / PCC, molecular sieves 4A / CH₂Cl₂ / 4 h

9: 31 percent / t-BuOK / benzene / 0.5 h / 0 °C

With 1H-imidazole; sodium hydroxide; sodium periodate; borane-THF; 4 A molecular sieve; potassium tert-butylate; dihydrogen peroxide; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)80440-3

Reference yield:

: 143135-48-2,143135-49-3
5-[(3aR,5S,6R,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-pentane-1,4-diol

: 143135-24-4
(3aR,4aS,5R,6S,8aR,8bR)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-hydroxy-2,2,5-trimethyl-hexahydro-benzo[4,5]furo[2,3-d][1,3]dioxol-7-one

Guidance literature:: Multi-step reaction with 6 steps

1: imidazole / dimethylformamide / 3 h

2: 64 percent / AcOH / tetrahydrofuran; H₂O / 15 h

3: 681 mg / NaIO₄ / methanol; H₂O / 1 h

4: 731 mg / tetrahydrofuran / 0.5 h / Heating

5: 558 mg / PCC, molecular sieves 4A / CH₂Cl₂ / 4 h

6: 31 percent / t-BuOK / benzene / 0.5 h / 0 °C

With 1H-imidazole; sodium periodate; 4 A molecular sieve; potassium tert-butylate; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)80440-3