phenylcarbamic acid 2-(bis-benzyloxy-phosphoryloxymethyl)-3-(2-chloro-6-methylamino-purin-9-yl)propyl ester

Base Information

Chemical Name:phenylcarbamic acid 2-(bis-benzyloxy-phosphoryloxymethyl)-3-(2-chloro-6-methylamino-purin-9-yl)propyl ester
CAS No.:491611-82-6
Molecular Formula:C₃₁H₃₂ClN₆O₆P
Molecular Weight:651.058
Hs Code.:

Synonyms:phenylcarbamic acid 2-(bis-benzyloxy-phosphoryloxymethyl)-3-(2-chloro-6-methylamino-purin-9-yl)propyl ester

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Chemical Property of phenylcarbamic acid 2-(bis-benzyloxy-phosphoryloxymethyl)-3-(2-chloro-6-methylamino-purin-9-yl)propyl ester

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Technology Process of phenylcarbamic acid 2-(bis-benzyloxy-phosphoryloxymethyl)-3-(2-chloro-6-methylamino-purin-9-yl)propyl ester

There total 5 articles about phenylcarbamic acid 2-(bis-benzyloxy-phosphoryloxymethyl)-3-(2-chloro-6-methylamino-purin-9-yl)propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 103-71-9
phenyl isocyanate

: 491611-78-0
phosphoric acid dibenzyl ester 3-(2-chloro-6-methylamino-purin-9-yl)-2-hydroxymethylpropyl ester

: 491611-82-6
phenylcarbamic acid 2-(bis-benzyloxy-phosphoryloxymethyl)-3-(2-chloro-6-methylamino-purin-9-yl)propyl ester

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1021/jm020173u

Reference yield:

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 491611-82-6
phenylcarbamic acid 2-(bis-benzyloxy-phosphoryloxymethyl)-3-(2-chloro-6-methylamino-purin-9-yl)propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-tetrazole / tetrahydrofuran / 0.33 h / 20 °C

2: 0.526 g / m-CPBA / CH₂Cl₂; tetrahydrofuran / 0.5 h / 20 °C

3: 87.6 percent / K₂CO₃ / methanol / 2 h / 20 °C

4: 68 percent / Et₃N / CH₂Cl₂

With 1H-tetrazole; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm020173u

Reference yield:

: 491611-75-7
[2-chloro-9-(2,2-dimethyl-[1,3]-dioxan-5-ylmethyl)-9H-purin-6-yl]methylamine

: 491611-82-6
phenylcarbamic acid 2-(bis-benzyloxy-phosphoryloxymethyl)-3-(2-chloro-6-methylamino-purin-9-yl)propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 30 percent / H₂O; tetrahydrofuran / 65 - 70 °C

2: 1H-tetrazole / tetrahydrofuran / 0.33 h / 20 °C

3: 0.526 g / m-CPBA / CH₂Cl₂; tetrahydrofuran / 0.5 h / 20 °C

4: 87.6 percent / K₂CO₃ / methanol / 2 h / 20 °C

5: 68 percent / Et₃N / CH₂Cl₂

With 1H-tetrazole; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm020173u