(R)-N-((S)-1-(4-bromophenyl)-2,2-difluoroethyl)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(R)-N-((S)-1-(4-bromophenyl)-2,2-difluoroethyl)-2-methylpropane-2-sulfinamide
CAS No.:1333259-60-1
Molecular Formula:C₁₂H₁₆BrF₂NOS
Molecular Weight:340.232
Hs Code.:

Synonyms:(R)-N-((S)-1-(4-bromophenyl)-2,2-difluoroethyl)-2-methylpropane-2-sulfinamide

Suppliers and Price of (R)-N-((S)-1-(4-bromophenyl)-2,2-difluoroethyl)-2-methylpropane-2-sulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-((S)-1-(4-bromophenyl)-2,2-difluoroethyl)-2-methylpropane-2-sulfinamide

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Technology Process of (R)-N-((S)-1-(4-bromophenyl)-2,2-difluoroethyl)-2-methylpropane-2-sulfinamide

There total 3 articles about (R)-N-((S)-1-(4-bromophenyl)-2,2-difluoroethyl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1448681-98-8
(N-Z)-N-[(4-bromophenyl)methylene]-(R)-2-methyl-propane-2-sulfinamide

: 65864-64-4
trimethyl(difluoromethyl)silane

: 1333259-60-1
(R)-N-((S)-1-(4-bromophenyl)-2,2-difluoroethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield:

: (R)-N-(4-bromobenzylidene)-2-methylpropane-2-sulfinamide

: 65864-64-4
trimethyl(difluoromethyl)silane

: 1333259-60-1
(R)-N-((S)-1-(4-bromophenyl)-2,2-difluoroethyl)-2-methylpropane-2-sulfinamide

: C₁₂H₁₆BrF₂NOS

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -78 - 20 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol202208b

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1333259-60-1
(R)-N-((S)-1-(4-bromophenyl)-2,2-difluoroethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / toluene / 16 h / 20 °C

2: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C

With potassium tert-butylate; sodium hydroxide; In tetrahydrofuran; toluene;