(S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-tert-butoxycarbonylamino-succinamic acid

Base Information

• Chemical Name: (S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-tert-butoxycarbonylamino-succinamic acid
• CAS No.: 55247-97-7
• Molecular Formula: C₂₄H₃₀N₂O₇
• Molecular Weight: 458.511
• Mol file: 55247-97-7.mol

Synonyms:(S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-tert-butoxycarbonylamino-succinamic acid

Chemical Property of (S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-tert-butoxycarbonylamino-succinamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-tert-butoxycarbonylamino-succinamic acid

There total 1 articles about (S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-tert-butoxycarbonylamino-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + H-Asn(Mbh)-OH (28252-52-0) → (S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-tert-butoxycarbonylamino-succinamic acid (55247-97-7)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 45 ℃; for 3h;

DOI:10.1002/recl.19800991107

Reference yield:

(S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-tert-butoxycarbonylamino-succinamic acid (55247-97-7) → L-asparaginylglycine (67576-72-1) + aspartylglycine (3790-51-0)

Guidance literature:

With dicyclohexyl-carbodiimide; trifluoroacetic acid; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 2.) CH₂Cl₂, 25 deg C, 40 min.;

DOI:10.1021/jo01292a001

upstream raw materials:

di-tert-butyl dicarbonate

H-Asn(Mbh)-OH

Downstream raw materials:

L-asparaginylglycine

aspartylglycine