Technology Process of (E)-1-(1-bromo-2-phenylvinyl)-1H-indole
There total 4 articles about (E)-1-(1-bromo-2-phenylvinyl)-1H-indole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(phenylethynyl)-1H-indole;
With
trimethylsilyl bromide;
In
dichloromethane;
at -78 ℃;
for 0.25h;
Inert atmosphere;
Large scale;
With
water;
In
dichloromethane;
at 20 ℃;
for 0.833333h;
stereoselective reaction;
Inert atmosphere;
Large scale;
DOI:10.1016/j.tetlet.2013.03.107
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1,10-Phenanthroline; potassium carbonate; copper(ll) sulfate pentahydrate / tetrahydrofuran / 80 °C / Inert atmosphere
2.1: trimethylsilyl bromide / dichloromethane / 0.25 h / -78 °C / Inert atmosphere; Large scale
2.2: 0.83 h / 20 °C / Inert atmosphere; Large scale
With
1,10-Phenanthroline; copper(ll) sulfate pentahydrate; trimethylsilyl bromide; potassium carbonate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2013.03.107
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide; silver nitrate / acetone / 2 h / 20 °C / Inert atmosphere
2.1: 1,10-Phenanthroline; potassium carbonate; copper(ll) sulfate pentahydrate / tetrahydrofuran / 80 °C / Inert atmosphere
3.1: trimethylsilyl bromide / dichloromethane / 0.25 h / -78 °C / Inert atmosphere; Large scale
3.2: 0.83 h / 20 °C / Inert atmosphere; Large scale
With
N-Bromosuccinimide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; trimethylsilyl bromide; potassium carbonate; silver nitrate;
In
tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/j.tetlet.2013.03.107
