3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-cyclopropyl-1H-pyrazol-5-yl}propanoic acid

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Chemical Name:3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-cyclopropyl-1H-pyrazol-5-yl}propanoic acid
CAS No.:926296-46-0
Molecular Formula:C₁₇H₁₆ClF₃N₂O₂
Molecular Weight:372.774
Hs Code.:

Synonyms:3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-cyclopropyl-1H-pyrazol-5-yl}propanoic acid

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Chemical Property of 3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-cyclopropyl-1H-pyrazol-5-yl}propanoic acid

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Technology Process of 3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-cyclopropyl-1H-pyrazol-5-yl}propanoic acid

There total 8 articles about 3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-cyclopropyl-1H-pyrazol-5-yl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1357002-33-5
ethyl 3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-cyclopropyl-1H-pyrazol-5-yl}propanoate

: 926296-47-1
3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-propyl-1H-pyrazol-5-yl}propanoic acid

: 926296-46-0
3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-cyclopropyl-1H-pyrazol-5-yl}propanoic acid

Guidance literature:: ethyl 3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-cyclopropyl-1H-pyrazol-5-yl}propanoate; With sodium hydroxide; ethanol; water; In tetrahydrofuran; at 50 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 926296-45-9
ethyl (E)-3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-cyclopropyl-1H-pyrazol-5-yl}propenoate

: 926296-47-1
3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-propyl-1H-pyrazol-5-yl}propanoic acid

: 926296-46-0
3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-cyclopropyl-1H-pyrazol-5-yl}propanoic acid

Guidance literature:: ethyl (E)-3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-cyclopropyl-1H-pyrazol-5-yl}propenoate; With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; under 760.051 Torr;

With sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃;

With hydrogenchloride; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmc.2011.12.008

Reference yield:

: 765-43-5
Cyclopropyl methyl ketone

: 926296-46-0
3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-cyclopropyl-1H-pyrazol-5-yl}propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / tetrahydrofuran / 20 °C

2.1: hydrazine hydrate; acetic acid / tetrahydrofuran / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 20 °C / Cooling with ice

5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C

5.2: -78 - 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Cooling with ice

6.2: 20 °C / Cooling

7.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 20 °C / 760.05 Torr

7.2: 50 °C

With oxalyl dichloride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium hydride; diisobutylaluminium hydride; potassium carbonate; hydrazine hydrate; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Claisen condensation / 5.1: Swern oxidation / 5.2: Swern oxidation / 6.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.bmc.2011.12.008