benzyl (E)-3-((tert-butoxycarbonyl)amino)acrylate

Base Information

• Chemical Name: benzyl (E)-3-((tert-butoxycarbonyl)amino)acrylate
• CAS No.: 1251841-09-4
• Molecular Formula: C₁₅H₁₉NO₄
• Molecular Weight: 277.32
• Mol file: 1251841-09-4.mol

Synonyms:benzyl (E)-3-((tert-butoxycarbonyl)amino)acrylate

Chemical Property of benzyl (E)-3-((tert-butoxycarbonyl)amino)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of benzyl (E)-3-((tert-butoxycarbonyl)amino)acrylate

There total 2 articles about benzyl (E)-3-((tert-butoxycarbonyl)amino)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

benzyl 3-((tert-butoxycarbonyl)amino)-4-oxo-4-(pyridin-4-ylthio)butanoate → benzyl (Z)-3-((tert-butoxycarbonyl)amino)acrylate + benzyl (E)-3-((tert-butoxycarbonyl)amino)acrylate (1251841-09-4)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); N-ethyl-N,N-diisopropylamine; catacxium A; In 1,4-dioxane; at 105 ℃; for 18h;

DOI:10.1021/ol101620r

Reference yield:

4-(benzyloxy)-2-(tert-butoxycarbonylamino)-4-oxobutanoic acid (147291-69-8,98482-77-0) → benzyl (Z)-3-((tert-butoxycarbonyl)amino)acrylate + benzyl (E)-3-((tert-butoxycarbonyl)amino)acrylate (1251841-09-4)

Guidance literature:

With 9-mesityl-2,7-dimethyl-10-phenylacridin-10-ium tetrafluoroborate; copper diacetate; In acetonitrile; for 14h; Overall yield = 97 %; Molecular sieve; Sealed tube; Inert atmosphere; Irradiation; Green chemistry;

DOI:10.1021/acs.joc.9b00167

upstream raw materials:

4-(benzyloxy)-2-(tert-butoxycarbonylamino)-4-oxobutanoic acid