Technology Process of 1-benzyl-3-(2,5-dioxo-2,3,3a,4,5,8b-hexahydro-1H-4,8a-diaza-as-indacen-3-yl)-1-methyl-urea
There total 20 articles about 1-benzyl-3-(2,5-dioxo-2,3,3a,4,5,8b-hexahydro-1H-4,8a-diaza-as-indacen-3-yl)-1-methyl-urea which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-Trimethylsilanyl-1H-pyrrole-2-carboxylic acid [(1R,5S)-5-(3-benzyl-3-methyl-ureido)-4-oxo-cyclopent-2-enyl]-amide;
With
N-Bromosuccinimide;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 3h;
With
N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 20 ℃;
for 18h;
With
water; hydrogen; sodium acetate;
palladium on activated charcoal;
In
methanol;
at 20 ℃;
for 2h;
under 760 Torr;
DOI:10.1021/ol0490476
- Guidance literature:
-
With
hydrogen; sodium acetate;
wet palladium on carbon;
In
methanol;
for 2h;
under 760.051 Torr;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: oxalyl chloride / CH2Cl2; dimethylformamide / 2 h / 20 °C
2.1: 10.5 g / Et3N; 4-dimethylaminopyridine / tetrahydrofuran
3.1: 60 percent / Bu3SnH; AIBN / toluene / 8 h / Heating
4.1: 40 percent / LiOH*H2O / tetrahydrofuran; H2O / 128 h / 20 °C
5.1: 73 percent / pyridinium dichromate / dimethylformamide / 2 h / 20 °C
6.1: N-bromosuccinimide / tetrahydrofuran / 3 h / 0 - 20 °C
6.2: i-Pr2NEt / tetrahydrofuran / 18 h / 20 °C
6.3: 35 percent / NaOAc; H2O; H2 / Pd/C / methanol / 2 h / 20 °C / 760 Torr
With
dmap; lithium hydroxide; N-Bromosuccinimide; dipyridinium dichromate; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol0490476
![5-Trimethylsilanyl-1H-pyrrole-2-carboxylic acid [(1R,5S)-5-(3-benzyl-3-methyl-ureido)-4-oxo-cyclopent-2-enyl]-amide](/Databaselist/images/loading.webp)
