{(2R,3R)-3-[(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-oxiranylmethyl]-2-methyl-oxiranyl}-methanol

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Chemical Name:{(2R,3R)-3-[(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-oxiranylmethyl]-2-methyl-oxiranyl}-methanol
CAS No.:565183-90-6
Molecular Formula:C₂₅H₃₄O₄Si
Molecular Weight:426.628
Hs Code.:

Synonyms:{(2R,3R)-3-[(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-oxiranylmethyl]-2-methyl-oxiranyl}-methanol

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Chemical Property of {(2R,3R)-3-[(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-oxiranylmethyl]-2-methyl-oxiranyl}-methanol

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Technology Process of {(2R,3R)-3-[(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-oxiranylmethyl]-2-methyl-oxiranyl}-methanol

There total 6 articles about {(2R,3R)-3-[(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-oxiranylmethyl]-2-methyl-oxiranyl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 565183-89-3
(E)-4-[(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-oxiranyl]-2-methyl-but-2-en-1-ol

: 565183-90-6
{(2R,3R)-3-[(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-oxiranylmethyl]-2-methyl-oxiranyl}-methanol

Guidance literature:: With titanium(IV) isopropylate; tert.-butylhydroperoxide; D-(-)-diisopropyl tartrate; 4 A molecular sieve; In decane; dichloromethane; at -18 ℃;
DOI:10.1021/ol034539o

Reference yield:

: 43160-61-8,103606-17-3,43161-23-5
(E)-3,6-dimethyl-2,5-heptadien-1-ol

: 565183-90-6
{(2R,3R)-3-[(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-oxiranylmethyl]-2-methyl-oxiranyl}-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: D-(-)-diisopropyl tartrate; Ti(i-PrO)4; t-BuOOH / 4 Angstroem molecular sieves / CH₂Cl₂; decane / -40 - -18 °C

2.1: imidazole / CH₂Cl₂ / 0.5 h / 0 °C

3.1: SeO₂; t-BuOOH; H₂O / CH₂Cl₂ / 48 h / 0 °C

3.2: 75 percent / NaBH₄ / methanol / 1 h / 0 °C

4.1: 100 percent / D-(-)-diisopropyl tartrate; Ti(i-PrO)4; t-BuOOH / 4 Angstroem molecular sieves / CH₂Cl₂; decane / -18 °C

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; selenium(IV) oxide; water; D-(-)-diisopropyl tartrate; 4 A molecular sieve; In decane; dichloromethane; 1.1: Sharpless asymmetric epoxidation / 4.1: Sharpless asymmetric epoxidation;
DOI:10.1021/ol034539o

Reference yield:

: 24529-80-4
(E)-1-O-acetyl-4-chloro-3-methyl-2-buten-1-ol

: 565183-90-6
{(2R,3R)-3-[(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-oxiranylmethyl]-2-methyl-oxiranyl}-methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 75 percent / MeOH; aq. Na₂CO₃ / 6 h / 0 °C

2.1: Mg; I₂ / tetrahydrofuran / 1 h / 20 °C

2.2: 87 percent / CuI / tetrahydrofuran; diethyl ether / 3 h / -50 °C

3.1: D-(-)-diisopropyl tartrate; Ti(i-PrO)4; t-BuOOH / 4 Angstroem molecular sieves / CH₂Cl₂; decane / -40 - -18 °C

4.1: imidazole / CH₂Cl₂ / 0.5 h / 0 °C

5.1: SeO₂; t-BuOOH; H₂O / CH₂Cl₂ / 48 h / 0 °C

5.2: 75 percent / NaBH₄ / methanol / 1 h / 0 °C

6.1: 100 percent / D-(-)-diisopropyl tartrate; Ti(i-PrO)4; t-BuOOH / 4 Angstroem molecular sieves / CH₂Cl₂; decane / -18 °C

With 1H-imidazole; titanium(IV) isopropylate; methanol; tert.-butylhydroperoxide; selenium(IV) oxide; water; iodine; sodium carbonate; D-(-)-diisopropyl tartrate; magnesium; 4 A molecular sieve; In tetrahydrofuran; decane; dichloromethane; 3.1: Sharpless asymmetric epoxidation / 6.1: Sharpless asymmetric epoxidation;
DOI:10.1021/ol034539o