N-[(1S-(1α,2α,1'α))-2-(2'-azido)ethan-1'-ol-cyclopropan-1-oyl]-L-phenylalanine-L-leucine methyl ester

Base Information

Chemical Name:N-[(1S-(1α,2α,1'α))-2-(2'-azido)ethan-1'-ol-cyclopropan-1-oyl]-L-phenylalanine-L-leucine methyl ester
CAS No.:264921-41-7
Molecular Formula:C₂₂H₃₁N₅O₅
Molecular Weight:445.519
Hs Code.:

Synonyms:N-[(1S-(1α,2α,1'α))-2-(2'-azido)ethan-1'-ol-cyclopropan-1-oyl]-L-phenylalanine-L-leucine methyl ester

Suppliers and Price of N-[(1S-(1α,2α,1'α))-2-(2'-azido)ethan-1'-ol-cyclopropan-1-oyl]-L-phenylalanine-L-leucine methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-[(1S-(1α,2α,1'α))-2-(2'-azido)ethan-1'-ol-cyclopropan-1-oyl]-L-phenylalanine-L-leucine methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[(1S-(1α,2α,1'α))-2-(2'-azido)ethan-1'-ol-cyclopropan-1-oyl]-L-phenylalanine-L-leucine methyl ester

There total 7 articles about N-[(1S-(1α,2α,1'α))-2-(2'-azido)ethan-1'-ol-cyclopropan-1-oyl]-L-phenylalanine-L-leucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 264921-40-6
N-[(1S-(1α,2α,1'α))-2-(2'-azido)ethan-1'-ol-cyclopropan-1-oyl]-L-phenylalanine-L-leucine

: 264921-41-7
N-[(1S-(1α,2α,1'α))-2-(2'-azido)ethan-1'-ol-cyclopropan-1-oyl]-L-phenylalanine-L-leucine methyl ester

Guidance literature:: In diethyl ether;
DOI:10.1021/jo991288h

Reference yield:

: 3303-55-7
L-Phe-Leu

: 264921-41-7
N-[(1S-(1α,2α,1'α))-2-(2'-azido)ethan-1'-ol-cyclopropan-1-oyl]-L-phenylalanine-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / Me₃Al / hexane; 1,2-dichloro-ethane / 24 h / Heating

2: 95 percent / diethyl ether

With trimethylaluminum; In diethyl ether; hexane; 1,2-dichloro-ethane; 1: Ring cleavage / 2: Esterification;
DOI:10.1021/jo991288h

Reference yield:

: 156418-79-0
1,4-pentadienyl-3-diazoacetate

: 264921-41-7
N-[(1S-(1α,2α,1'α))-2-(2'-azido)ethan-1'-ol-cyclopropan-1-oyl]-L-phenylalanine-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: Rh₂[(5S)-MEPY]4 / CH₂Cl₂ / Heating

2.1: O₃ / methanol; CH₂Cl₂ / -78 °C

2.2: 60 percent / NaBH₄ / methanol; CH₂Cl₂ / 0.5 h / -78 - 0 °C

3.1: 90 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

4.1: 0.15 g / NaN₃ / dimethylformamide / 12 h / 65 °C

5.1: 60 percent / Me₃Al / hexane; 1,2-dichloro-ethane / 24 h / Heating

6.1: 95 percent / diethyl ether

With sodium azide; Rh₂[(2S)-5-hydroxypyrrolidine-2-COOMe]4; trimethylaluminum; ozone; triethylamine; In methanol; diethyl ether; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1.1: Cyclization / 2.1: ozonolysis / 2.2: Reduction / 3.1: Condensation / 4.1: Substitution / 5.1: Ring cleavage / 6.1: Esterification;
DOI:10.1021/jo991288h