(+/-)-6-benzyloxy-2-(2,5-dimethoxybenzyl)-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(+/-)-6-benzyloxy-2-(2,5-dimethoxybenzyl)-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:1064205-47-5
Molecular Formula:C₂₇H₃₁NO₄
Molecular Weight:433.547
Hs Code.:

Synonyms:(+/-)-6-benzyloxy-2-(2,5-dimethoxybenzyl)-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-6-benzyloxy-2-(2,5-dimethoxybenzyl)-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (+/-)-6-benzyloxy-2-(2,5-dimethoxybenzyl)-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

There total 13 articles about (+/-)-6-benzyloxy-2-(2,5-dimethoxybenzyl)-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1064202-11-4
(+/-)-6-benzyloxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

: 3840-27-5
2,5-dimethoxybenzyl chloride

: 1064205-47-5
(+/-)-6-benzyloxy-2-(2,5-dimethoxybenzyl)-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 20h;

Reference yield: 76.0%

: 1064203-14-0
(+/-)-3-ethyl-6-benzyloxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline

: 3840-27-5
2,5-dimethoxybenzyl chloride

: 1064205-47-5
(+/-)-6-benzyloxy-2-(2,5-dimethoxybenzyl)-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 20h; Microwave irradiation;
DOI:10.1002/cmdc.201300412

Reference yield:

: 6346-05-0
3-benzyloxy-4-methoxybenzaldehyde

: 1064205-47-5
(+/-)-6-benzyloxy-2-(2,5-dimethoxybenzyl)-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1: ammonium acetate / 22 h / 120 °C

2: sodium tetrahydroborate / ethanol; tetrahydrofuran / 66 h / 0 - 20 °C

3: nickel; hydrazine hydrate / methanol / 8 h / 0 - 50 °C

4: triethylamine; acetic anhydride / dichloromethane / 4 h / 0 °C

5: toluene-4-sulfonic acid / toluene / 16 h / 120 °C

6: potassium hydroxide / ethanol; water / 66 h / 120 °C

7: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 80 °C / Microwave irradiation

With sodium tetrahydroborate; ammonium acetate; acetic anhydride; nickel; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201300412