(S)-Pyrrolidin-2-yldi-p-tolylmethanol

Base Information

Chemical Name:(S)-Pyrrolidin-2-yldi-p-tolylmethanol
CAS No.:131180-52-4
Molecular Formula:C19H23NO
Molecular Weight:281.39202
Hs Code.:2933990090
DSSTox Substance ID:DTXSID401226695
Nikkaji Number:J2.003.050J
Mol file:131180-52-4.mol

Synonyms:131180-52-4;(S)-Pyrrolidin-2-yldi-p-tolylmethanol;(S)-alpha,alpha-Bis(4-methylphenyl)-2-pyrrolidinemethanol;Bis(4-methylphenyl)-[(2S)-pyrrolidin-2-yl]methanol;2-Pyrrolidinemethanol, alpha,alpha-bis(4-methylphenyl)-, (2S)-;SCHEMBL9230937;(2s)-alpha,alpha-bis(4-methylphenyl)-2-pyrrolidinemethanol;DTXSID401226695;AKOS015912300;AS-69745;CS-0085697;D74603;bis(4-methylphenyl)[(2S)-pyrrolidin-2-yl]methanol;2-Pyrrolidinemethanol,a,a-bis(4-methylphenyl)-,(2S)-

Suppliers and Price of (S)-Pyrrolidin-2-yldi-p-tolylmethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(S)-ALPHA,ALPHA-BIS-(4-METHYLPHENYL)-2-PYRROLIDINEMETHANOL 95.00%
5MG
$ 502.02

Total 22 raw suppliers

Chemical Property of (S)-Pyrrolidin-2-yldi-p-tolylmethanol

Chemical Property:

Melting Point:93-94 °C
Boiling Point:442.3 °C at 760 mmHg
PKA:13.42±0.29(Predicted)
Flash Point:123.3 °C
PSA：32.26000
Density:1.094g/cm³
LogP:3.62010
XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:281.177964357
Heavy Atom Count:21
Complexity:305

Purity/Quality:

99% ^*data from raw suppliers

(S)-ALPHA,ALPHA-BIS-(4-METHYLPHENYL)-2-PYRROLIDINEMETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C(C2CCCN2)(C3=CC=C(C=C3)C)O
Isomeric SMILES:CC1=CC=C(C=C1)C([C@@H]2CCCN2)(C3=CC=C(C=C3)C)O

Technology Process of (S)-Pyrrolidin-2-yldi-p-tolylmethanol

There total 6 articles about (S)-Pyrrolidin-2-yldi-p-tolylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 45736-33-2
(S)-proline-N-carboxyanhydride

: 4294-57-9
para-methylphenylmagnesium bromide

: 131180-52-4
(S)-α,α-Bis(4-methylphenyl)-2-pyrrolidinemethanol

Guidance literature:: In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00002a049

Reference yield:

: 1010721-59-1
(S)-(1-benzylpyrrolidin-2-yl)di-p-tolylmethanol

: 131180-52-4
(S)-α,α-Bis(4-methylphenyl)-2-pyrrolidinemethanol

Guidance literature:: With hydrogenchloride; hydrogen; In ethanol; at 20 ℃; for 8h;

Reference yield:

: 77581-28-3,93423-88-2
(S)-proline-N-ethyl carbamate methyl ester

: 131180-52-4
(S)-α,α-Bis(4-methylphenyl)-2-pyrrolidinemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 °C

2: KOH / methanol / 4 h

With potassium hydroxide; In tetrahydrofuran; methanol; 1: Grignard reaction;
DOI:10.1016/S0957-4166(02)00789-9