methyl (R)-7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate

Base Information

Chemical Name:methyl (R)-7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate
CAS No.:156558-10-0
Molecular Formula:C₂₆H₃₃FO₄
Molecular Weight:428.544
Hs Code.:

Synonyms:methyl (R)-7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (R)-7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate

Chemical Property:

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Technology Process of methyl (R)-7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate

There total 4 articles about methyl (R)-7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: methyl (R)-7-(4-fluorophenyl)-7-[3-(1-hydroxyethyl)-6-methoxy-2,4,5-trimethylphenyl]heptanoate

: 156558-10-0
methyl (R)-7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1248/cpb.44.749

Reference yield:

: 697-82-5
2,3,5-trimethylphenol

: 156558-10-0
methyl (R)-7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl azodicarboxylate, Ph₃P / 1,2-dichloro-ethane / 1 h / 10 °C

2: 75 percent / TiCl₄ / CH₂Cl₂ / 0.33 h / -12 - -10 °C

3: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1.5 h

4: 94 percent / tetrahydrofuran / 0.5 h / -78 °C

5: 96 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

With titanium tetrachloride; sodium hydride; triphenylphosphine; pyridinium chlorochromate; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1248/cpb.44.749

Reference yield:

: 156558-16-6
methyl (S)-7-(4-fluorophenyl)-7-hydroxyheptanoate

: 156558-10-0
methyl (R)-7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl azodicarboxylate, Ph₃P / 1,2-dichloro-ethane / 1 h / 10 °C

2: 75 percent / TiCl₄ / CH₂Cl₂ / 0.33 h / -12 - -10 °C

3: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1.5 h

4: 94 percent / tetrahydrofuran / 0.5 h / -78 °C

5: 96 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

With titanium tetrachloride; sodium hydride; triphenylphosphine; pyridinium chlorochromate; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1248/cpb.44.749