(S)-2-((2R,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionic acid benzyl ester

Base Information

Chemical Name:(S)-2-((2R,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionic acid benzyl ester
CAS No.:126583-18-4
Molecular Formula:C₂₇H₃₆N₂O₅
Molecular Weight:468.593
Hs Code.:

Synonyms:(S)-2-((2R,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionic acid benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-((2R,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionic acid benzyl ester

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Technology Process of (S)-2-((2R,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionic acid benzyl ester

There total 1 articles about (S)-2-((2R,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 962-39-0
L-Phenylalanine benzyl ester

: 55721-65-8
Boc-D-Ile-OH

: 126583-18-4
(S)-2-((2R,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1.) -15 deg C, 1h; 2.) 4 deg C, 15 h;
DOI:10.1248/cpb.37.3108

Reference yield: 82.0%

: 126583-18-4
(S)-2-((2R,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionic acid benzyl ester

: 116109-70-7
(S)-2-((2R,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionic acid

Guidance literature:: With hydrogen; palladium; In methanol;
DOI:10.1248/cpb.37.3108

Reference yield:

: 126583-18-4
(S)-2-((2R,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-phenyl-propionic acid benzyl ester

: C₂₂H₃₅ClN₄O₃*2BrH*2H₂O

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / H₂ / Pd / methanol

2: 13 percent / DCC-HOBt

3: 55 percent / 25percent HBr-AcOH / 1 h / Ambient temperature

With hydrogen bromide; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium; In methanol;
DOI:10.1248/cpb.37.3108