N²-(4-chloro-phenyl)-N⁴-(2-pyrrolidino-ethyl)-quinazoline-2,4-diyldiamine; dihydrochloride

Base Information

• Chemical Name: N²-(4-chloro-phenyl)-N⁴-(2-pyrrolidino-ethyl)-quinazoline-2,4-diyldiamine; dihydrochloride
• CAS No.: 76004-65-4
• Molecular Formula: C₂₀H₂₂ClN₅*2ClH
• Molecular Weight: 440.803

Synonyms:N²-(4-chloro-phenyl)-N⁴-(2-pyrrolidino-ethyl)-quinazoline-2,4-diyldiamine; dihydrochloride

Chemical Property of N²-(4-chloro-phenyl)-N⁴-(2-pyrrolidino-ethyl)-quinazoline-2,4-diyldiamine; dihydrochloride

Chemical Property:

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Technology Process of N²-(4-chloro-phenyl)-N⁴-(2-pyrrolidino-ethyl)-quinazoline-2,4-diyldiamine; dihydrochloride

There total 2 articles about N²-(4-chloro-phenyl)-N⁴-(2-pyrrolidino-ethyl)-quinazoline-2,4-diyldiamine; dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-chloro-aniline (106-47-8) + 2-chloro-N-<2-(1-pyrrolidinyl)ethyl>-4-quinazolinamine (76004-35-8) → N2-(4-chloro-phenyl)-N4-(2-pyrrolidino-ethyl)-quinazoline-2,4-diyldiamine; dihydrochloride (76004-65-4)

Guidance literature:

With hydrogenchloride; In ethanol; for 3h; Heating;

DOI:10.1021/jm00134a002

Reference yield:

1-(2-aminoethyl)pyrrolidine (7154-73-6) → N2-(4-chloro-phenyl)-N4-(2-pyrrolidino-ethyl)-quinazoline-2,4-diyldiamine; dihydrochloride (76004-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / diethyl ether / 1.5 h

2: 66 percent / conc. HCl / ethanol / 3 h / Heating

With hydrogenchloride; In diethyl ether; ethanol;

DOI:10.1021/jm00134a002

upstream raw materials:

4-chloro-aniline

2-chloro-N-<2-(1-pyrrolidinyl)ethyl>-4-quinazolinamine

1-(2-aminoethyl)pyrrolidine

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