6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid

Base Information

Chemical Name:6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
CAS No.:1467057-23-3
Molecular Formula:C₁₉H₁₆ClNO₃
Molecular Weight:341.794
Hs Code.:
Mol file:1467057-23-3.mol

Synonyms:6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylic acid

Suppliers and Price of 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
PF06409577
1mg
$ 55.00

TRC
PF06409577
10mg
$ 275.00

Tocris
PF06409577 ≥98%(HPLC)
10
$ 179.00

Tocris
PF06409577 ≥98%(HPLC)
50
$ 731.00

DC Chemicals
PF-06409577 >98%
250 mg
$ 950.00

ChemScene
PF-06409577 99.07%
100mg
$ 810.00

ChemScene
PF-06409577 99.07%
25mg
$ 280.00

ChemScene
PF-06409577 99.07%
5mg
$ 70.00

ChemScene
PF-06409577 99.07%
50mg
$ 480.00

ChemScene
PF-06409577 99.07%
10mg
$ 120.00

Total 16 raw suppliers

Chemical Property of 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid

Chemical Property:

Boiling Point:610.9±55.0 °C(Predicted)
PKA:3.60±0.30(Predicted)
Density:1.468±0.06 g/cm3(Predicted)
Storage Temp.:room temp

Purity/Quality:

99%, ^*data from raw suppliers

PF06409577 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description PF-06409577 is an activator of AMP-activated protein kinase (AMPK) heterotrimers (Kd = 9 nM for α1β1γ1). In vitro, it selectively activates β1-containing AMPK isoforms (EC50s = 2.18-7.03 nM) over β2-containing isoforms (EC50s = ≥10 μM). PF-06409577 has an EC50 value of 7 nM in an activation/protection TR-FRET assay using α1β1γ1 AMPK. In vivo, PF-06409577 (≥10 mg/kg) increases phosphorylation of AMPK in rat kidney. It decreases urinary albumin levels in a ZSF1 obese rat model of diabetes, metabolic syndrome, and renal disease when administered at a dose of 100 mg/kg.
Uses PF-06409577 has been used to determine its potential as a therapeutic agent for diabetic nephropathy.

Technology Process of 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid

There total 13 articles about 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1467059-92-2
methyl 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylate

: 1467057-23-3
6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; water; at 63 ℃; for 13.5h; Inert atmosphere; Large scale;
DOI:10.1021/acs.oprd.8b00059

Reference yield: 71.0%

: 1467059-90-0
6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carbaldehyde

: 1467057-23-3
6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylic acid

Guidance literature:: With sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; In water; acetonitrile; tert-butyl alcohol; at 20 ℃; for 22h;

Reference yield:

: 19936-14-2
1-(4-bromophenyl)cyclobutan-1-ol

: 1467057-23-3
6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; ethanol; toluene / 2 h / 110 °C / Inert atmosphere

3: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogen phosphate monohydrate / water; acetonitrile; tert-butyl alcohol / 22 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; potassium acetate; potassium carbonate; In 1,4-dioxane; ethanol; water; toluene; acetonitrile; tert-butyl alcohol;