2,3-Dichloro-6-nitroquinoxaline

Base Information

• Chemical Name: 2,3-Dichloro-6-nitroquinoxaline
• CAS No.: 2379-60-4
• Molecular Formula: C8H3Cl2N3O2
• Molecular Weight: 244.037
• Hs Code.: 2933990090
• European Community (EC) Number: 626-315-9
• DSSTox Substance ID: DTXSID00351044
• Nikkaji Number: J1.270.059H
• Wikidata: Q72467178
• ChEMBL ID: CHEMBL5169397
• Mol file: 2379-60-4.mol

Synonyms:2,3-Dichloro-6-nitroquinoxaline;2379-60-4;2 3-Dichloro-6-nitroquinoxaline;2,3-Dichloro-6-Nitro-Quinoxaline;2,3-Dichloro-6-nitroqunioxaline;quinoxaline, 2,3-dichloro-6-nitro-;23-Dichloro-6-nitroquinoxaline;SCHEMBL1259501;CHEMBL5169397;6-nitro-2,3-dichloroquinoxaline;DTXSID00351044;SFJCUOAQTGDBPO-UHFFFAOYSA-N;AMY24883;MFCD00454905;STK786143;AKOS005621576;AKOS015912993;AC-9266;CCG-321585;AS-37662;CS-0105603;D4757;EN300-5597547;A816910;J-015215;Z1509532599;potassium 7-isopropyl-1,4a-dimethyl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylate;2,3-DICHLORO-6-NITROQUINOXALINE

Chemical Property of 2,3-Dichloro-6-nitroquinoxaline

Chemical Property:

• Vapor Pressure: 4.16E-05mmHg at 25°C
• Melting Point: 151-155 °C(lit.)
• Refractive Index: 1.704
• Boiling Point: 361.979 °C at 760 mmHg
• PKA: -7.43±0.48(Predicted)
• Flash Point: 172.719 °C
• PSA: 71.60000
• Density: 1.674 g/cm³
• LogP: 3.36800
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Dimethylformamide
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 242.9602317
• Heavy Atom Count: 15
• Complexity: 261

Purity/Quality:

97% ^*data from raw suppliers

2,3-Dichloro-6-nitroquinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-37/38-41
• Safety Statements: 22-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=C1[N+](=O)[O-])N=C(C(=N2)Cl)Cl

Technology Process of 2,3-Dichloro-6-nitroquinoxaline

There total 8 articles about 2,3-Dichloro-6-nitroquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,3-dihydroxy-6-nitroquinoxaline (2379-56-8) → 2,3-dichloro-6-nitroquinoxaline (2379-60-4)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In 1,2-dichloro-ethane; for 4h; Reflux;

DOI:10.1002/jhet.56

Reference yield: 95.0%

6-nitro-1,2,3,4-tetrahydroquinoxaline-2,3-dione (2379-56-8) → 2,3-dichloro-6-nitroquinoxaline (2379-60-4)

Guidance literature:

With trichlorophosphate; for 6h; Reflux;

DOI:10.1016/j.bioorg.2014.05.010

Reference yield:

4-Nitrophenylene-1,2-diamine (99-56-9) → 2,3-dichloro-6-nitroquinoxaline (2379-60-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / 24 h / Heating

2: 66 percent / POCl₃ / 3.5 h / Heating

With trichlorophosphate;

DOI:10.1016/j.bmcl.2007.01.094

upstream raw materials:

6-nitro-1,2,3,4-tetrahydroquinoxaline-2,3-dione

2,3-dihydroxy-6-nitroquinoxaline

4-Nitrophenylene-1,2-diamine

2,3-diethynylquinoxaline

Downstream raw materials:

(6-nitro-3-m-tolyl-3H-thiazolo[4,5-b]quinoxalin-2-ylidene)-m-tolyl-amine

(6-nitro-3-o-tolyl-3H-thiazolo[4,5-b]quinoxalin-2-ylidene)-o-tolyl-amine

(3-chloro-phenyl)-[3-(3-chloro-phenyl)-6-nitro-3H-thiazolo[4,5-b]quinoxalin-2-ylidene]-amine

(2-methoxy-phenyl)-[3-(2-methoxy-phenyl)-6-nitro-3H-thiazolo[4,5-b]quinoxalin-2-ylidene]-amine