N-methyl-2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-acetamide

Base Information

• Chemical Name: N-methyl-2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-acetamide
• CAS No.: 932036-98-1
• Molecular Formula: C₁₇H₁₆F₃NO₃
• Molecular Weight: 339.314
• Mol file: 932036-98-1.mol

Synonyms:N-methyl-2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-acetamide

Chemical Property of N-methyl-2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-acetamide

There total 5 articles about N-methyl-2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-acetamide (932036-97-0) + methyl bromide (74-83-9) → 2-phenoxy-N-[4-(2,2,2-trifluoro-1-methoxy-ethyl)-phenyl]-acetamide + N-methyl-2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-acetamide (932036-98-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmcl.2006.09.023

Reference yield:

2-phenoxy-N-(4-trifluoroacetyl-phenyl)-acetamide (449804-45-9) → N-methyl-2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-acetamide (932036-98-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / methanol

2: NaH / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2006.09.023

Reference yield:

4-nitrobenzoic acid methyl ester (619-50-1) → N-methyl-2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-acetamide (932036-98-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: TBAF / CH₂Cl₂ / -78 - 20 °C

1.2: 92 percent / aq. HCl / acetone

2.1: 79 percent / Fe; AcOH / ethanol / Heating

3.1: diethylamine / CH₂Cl₂ / 20 °C

4.1: NaBH₄ / methanol

5.1: NaH / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; iron; sodium hydride; acetic acid; diethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.09.023

upstream raw materials:

2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-acetamide

methyl bromide

2-phenoxy-N-(4-trifluoroacetyl-phenyl)-acetamide

4-nitrobenzoic acid methyl ester

Downstream raw materials:

N-methyl-2-phenoxy-N-(4-trifluoroacetyl-phenyl)-acetamide