(R)-4-((S)-4-(benzyloxy)butan-2-yl)-2,2-dimethyl-1,3-dioxolane

Base Information

• Chemical Name: (R)-4-((S)-4-(benzyloxy)butan-2-yl)-2,2-dimethyl-1,3-dioxolane
• CAS No.: 1415654-73-7
• Molecular Formula: C₁₆H₂₄O₃
• Molecular Weight: 264.365
• Mol file: 1415654-73-7.mol

Synonyms:(R)-4-((S)-4-(benzyloxy)butan-2-yl)-2,2-dimethyl-1,3-dioxolane

Chemical Property of (R)-4-((S)-4-(benzyloxy)butan-2-yl)-2,2-dimethyl-1,3-dioxolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-((S)-4-(benzyloxy)butan-2-yl)-2,2-dimethyl-1,3-dioxolane

There total 1 articles about (R)-4-((S)-4-(benzyloxy)butan-2-yl)-2,2-dimethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trimethylaluminum (75-24-1) + (2S,3R)-3-[2-(benzyloxy)ethyl]oxiran-2-methanol (126107-73-1) → (4R,5R)-4-(2-Benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxane + (R)-4-((S)-4-(benzyloxy)butan-2-yl)-2,2-dimethyl-1,3-dioxolane (1415654-73-7)

Guidance literature:

trimethylaluminum; (2S,3R)-3-[2-(benzyloxy)ethyl]oxiran-2-methanol; In dichloromethane; toluene; pentane; at 0 - 20 ℃; for 8h; Inert atmosphere;

With toluene-4-sulfonic acid; In acetone; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jo302205t

Reference yield: 85.0%

(R)-4-((S)-4-(benzyloxy)butan-2-yl)-2,2-dimethyl-1,3-dioxolane (1415654-73-7) → (2R,3S)-5-(benzyloxy)-3-methylpentane-1,2-diol (1415654-74-8)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 24h;

DOI:10.1021/jo302205t

Reference yield:

(R)-4-((S)-4-(benzyloxy)butan-2-yl)-2,2-dimethyl-1,3-dioxolane (1415654-73-7) → (R)-2-((S)-4-(benzyloxy)butan-2-yl)oxirane (1415654-75-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / methanol / 24 h / 20 °C

2: sodium hydride; N-tosylimidazole / mineral oil; tetrahydrofuran / 0.5 h / 0 °C

With sodium hydride; toluene-4-sulfonic acid; N-tosylimidazole; In tetrahydrofuran; methanol; mineral oil;

DOI:10.1021/jo302205t

upstream raw materials:

trimethylaluminum

(2S,3R)-3-[2-(benzyloxy)ethyl]oxiran-2-methanol

Downstream raw materials:

(2R,3S)-5-(benzyloxy)-3-methylpentane-1,2-diol

(R)-2-((S)-4-(benzyloxy)butan-2-yl)oxirane

(4S,5S)-7-(benzyloxy)-5-methylhept-1-en-4-ol