(3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-?uoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-5-methylhexanoic acid

Base Information

Chemical Name:(3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-?uoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-5-methylhexanoic acid
CAS No.:1073544-45-2
Molecular Formula:C₃₁H₃₇FO₄
Molecular Weight:492.631
Hs Code.:

Synonyms:(3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-?uoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-5-methylhexanoic acid

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Chemical Property of (3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-?uoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-5-methylhexanoic acid

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Technology Process of (3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-?uoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-5-methylhexanoic acid

There total 8 articles about (3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-?uoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-5-methylhexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1073547-00-8
methyl (3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-5-methylhexanoate

: 1073544-45-2
(3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-?uoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-5-methylhexanoic acid

Guidance literature:: methyl (3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-5-methylhexanoate; With sodium hydroxide; ethanol; water; In tetrahydrofuran; at 23 ℃; for 19h;

With hydrogenchloride; water; pH=1;

Reference yield:

: 1012070-84-6
C₁₄H₁₈O₃

: 1073544-45-2
(3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-?uoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-5-methylhexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: Resolution of racemate

2.1: hydrogen / palladium over charcoal / ethyl acetate / 2 h / 23 °C

3.1: N,N-dimethyl-formamide / 22 h / 0 - 23 °C

4.1: sodium hydroxide; ethanol; water / tetrahydrofuran / 19 h / 23 °C

4.2: pH 1

With sodium hydroxide; ethanol; water; hydrogen; palladium over charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1012070-85-7
methyl (3S)-3-(4-hydroxyphenyl)-5-methyl-4-hexenoate

: 1073544-45-2
(3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-?uoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-5-methylhexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium over charcoal / ethyl acetate / 2 h / 23 °C

2.1: N,N-dimethyl-formamide / 22 h / 0 - 23 °C

3.1: sodium hydroxide; ethanol; water / tetrahydrofuran / 19 h / 23 °C

3.2: pH 1

With sodium hydroxide; ethanol; water; hydrogen; palladium over charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;